Table 1 Novel candidate BRI2 interacting proteins highly enriched or specific for the brain tissue. Uniprot accession numbers, gene and protein names, are listed, as well as the rat brain tissues where the proteins were found. CC, cerebral cortex; HP, hippocampus; CB, cerebellum.

P13233

Cnp

2′,3′-cyclic-nucleotide 3′-phosphodiesterase

CC, HP, CB

P23565

Ina

Alpha-internexin

CC, HP, CB

O08838

Amph

Amphiphysin

CC, HP, CB

P0C6S7

Anks1b

Ankyrin repeat and sterile alpha motif domain-containing protein 1B

CC

Q8CGU4

Agap2

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

CC

Q6PST4

Atl1

Atlastin-1

CC

Q05764

Add2

Beta-adducin

HP

P85969

Napb

Beta-soluble NSF attachment protein

HP

Q05175

Basp1

Brain acid soluble protein 1

HP

P55068

Bcan

Brevican core protein

HP, CB

P11275

Camk2a

Calcium/calmodulin-dependent protein kinase type II subunit alpha

CC, HP

P08413

Camk2b

Calcium/calmodulin-dependent protein kinase type II subunit beta

CC, HP, CB

Q62717

Cadps

Calcium-dependent secretion activator 1

HP

Q63092

Camkv

CaM kinase-like vesicle-associated protein

HP

Q1WIM1

Cadm4

Cell adhesion molecule 4

CB

Q5FVI4

Cend1

Cell cycle exit and neuronal differentiation protein 1

CC, HP

Q05140

Snap91

Clathrin coat assembly protein AP180

CC, HP

P63041

Cplx1

Complexin-1

HP

Q9Z1T4

Cnksr2

Connector enhancer of kinase suppressor of ras 2

CC

Q63198

Cntn1

Contactin-1

CC, HP

P97846

Cntnap1

Contactin-associated protein 1

CC, CB

Q5BJS7

Cpne9

Copine-9

HP

Q62950

Crmp1

Dihydropyrimidinase-related protein 1

HP

Q62951

Dpysl4

Dihydropyrimidinase-related protein 4

CB

Q63622

Dlg2

Disks large homolog 2

CC

P31016

Dlg4

Disks large homolog 4

CC, HP, CB

P97836

Dlgap1

Disks large-associated protein 1

CC

P97837

Dlgap2

Disks large-associated protein 2

CC

P97838

Dlgap3

Disks large-associated protein 3

CC

P21575

Dnm1

Dynamin-1

CC, HP

Q8R491

Ehd3

EH domain-containing protein 3

HP

Q8CH84

Elavl2

ELAV-like protein 2

CC

O35179

Sh3gl2

Endophilin-A1

CC, CB

P24942

Slc1a3

Excitatory amino acid transporter 1

CC, HP, CB

P31596

Slc1a2

Excitatory amino acid transporter 2

CC, HP, CB

O35921

Slc1a6

Excitatory amino acid transporter 4

CB

O88871

Gabbr2

Gamma-aminobutyric acid type B receptor subunit 2

CC

P47819

Gfap

Glial fibrillary acidic protein

CC, HP, CB

P19490

Gria1

Glutamate receptor 1

CC

P19491

Gria2

Glutamate receptor 2

CC, HP, CB

P35439

Grin1

Glutamate receptor ionotropic, NMDA 1

CC

Q00960

Grin2b

Glutamate receptor ionotropic, NMDA 2B

CC

Q9WTT6

Gda

Guanine deaminase

CC

P19627

Gnaz

Guanine nucleotide-binding protein G

CC, HP

P59215

Gnao1

Guanine nucleotide-binding protein G

CC, HP, CB

Q9Z214

Homer1

Homer protein homolog 1

CC

Q9ESM2

Hapln2

Hyaluronan and proteoglycan link protein 2

CC, CB

Q9QYU4

Crym

Ketimine reductase mu-crystallin

HP

Q6QLM7

Kif5a

Kinesin heavy chain isoform 5 A

CC, HP, CB

P56536

Kif5c

Kinesin heavy chain isoform 5 C

CC, CB

P37285

Klc1

Kinesin light chain 1

CC, HP, CB

Q62813

Lsamp

Limbic system-associated membrane protein

CC, CB

P34926

Map1a

Microtubule-associated protein 1 A

CC, HP

P15205

Map1b

Microtubule-associated protein 1B

CC, HP, CB

P15146

Map2

Microtubule-associated protein 2

CC

Q63560

Map6

Microtubule-associated protein 6

CC, HP, CB

Q505J6

Slc25a18

Mitochondrial glutamate carrier 2

CC

P02688

Mbp

Myelin basic protein

CC

P60203

Plp1

Myelin proteolipid protein

CC, CB

P07722

Mag

Myelin-associated glycoprotein

CC, CB

Q63345

Mog

Myelin-oligodendrocyte glycoprotein

CC, CB

P13596

Ncam1

Neural cell adhesion molecule 1

CB

P55067

Ncan

Neurocan core protein

CC, HP, CB

O35095

Ncdn

Neurochondrin

CC

P19527

Nefl

Neurofilament light polypeptide

CC, HP, CB

P12839

Nefm

Neurofilament medium polypeptide

CC, CB

P07936

Gap43

Neuromodulin

CC

Q9ESI7

Dcx

Neuronal migration protein doublecortin

CC

Q9WU34

Sept3

Neuronal-specific septin-3

HP

Q62718

Ntm

Neurotrimin

CC, CB

P11506

Atp2b2

Plasma membrane calcium-transporting ATPase 2

CC

Q64568

Atp2b3

Plasma membrane calcium-transporting ATPase 3

HP

P10499

Kcna1

Potassium voltage-gated channel subfamily A member 1

CC

Q6MG82

Prrt1

Proline-rich transmembrane protein 1

HP

O88778

Bsn

Protein bassoon

CC, CB

P63319

Prkcg

Protein kinase C gamma type

CC, HP, CB

Q9JKS6

Pclo

Protein piccolo

CC

P47709

Rph3a

Rabphilin-3A

CC, HP

P63012

Rab3a

Ras-related protein Rab-3A

CC, HP, CB

P62824

Rab3c

Ras-related protein Rab-3C

CC, HP

Q9JIR4

Rims1

Regulating synaptic membrane exocytosis protein 1

CC

Q64548

Rtn1

Reticulon-1

CC, HP, CB

Q9JKE3

Scamp5

Secretory carrier-associated membrane protein 5

CC, HP

Q9JJM9

Sept5

Septin-5

CC, HP

O08875

Dclk1

Serine/threonine-protein kinase DCLK1

CC, HP

Q9WV48

Shank1

SH3 and multiple ankyrin repeat domains protein 1

CC, CB

P0DJJ3

Sgip1

SH3-containing GRB2-like protein 3-interacting protein 1

CC, HP

P31647

Slc6a11

Sodium- and chloride-dependent GABA transporter 3

CC, CB

P48768

Slc8a2

Sodium/calcium exchanger 2

CC

P06686

Atp1a2

Sodium/potassium-transporting ATPase subunit alpha-2

CC

P06687

Atp1a3

Sodium/potassium-transporting ATPase subunit alpha-3

CC, HP

P13638

Atp1b2

Sodium/potassium-transporting ATPase subunit beta-2

CC, HP, CB

Q63633

Slc12a5

Solute carrier family 12 member 5

HP

Q9QWN8

Sptbn2

Spectrin beta chain, non-erythrocytic 2

CC, CB

Q9QXY2

Srcin1

SRC kinase signaling inhibitor 1

CC, CB

P09951

Syn1

Synapsin-1

CC, HP

Q63537

Syn2

Synapsin-2

CC

Q02563

Sv2a

Synaptic vesicle glycoprotein 2 A

CC, HP, CB

Q63564

Sv2b

Synaptic vesicle glycoprotein 2B

CC, HP

P07825

Syp

Synaptophysin

CC, HP

P60881

Snap25

Synaptosomal-associated protein 25

HP, CB

P21707

Syt1

Synaptotagmin-1

CC, HP, CB

P97610

Syt12

Synaptotagmin-12

CC, CB

P29101

Syt2

Synaptotagmin-2

CB

Q62747

Syt7

Synaptotagmin-7

CB

P32851

Stx1a

Syntaxin-1A

CC

P61265

Stx1b

Syntaxin-1B

CC, HP, CB

P61765

Stxbp1

Syntaxin-binding protein 1

CC, HP

Q05546

Tnr

Tenascin-R

CC, HP, CB

P70566

Tmod2

Tropomodulin-2

CC, CB

P85108

Tubb2a

Tubulin beta-2A chain

CC, HP, CB

Q3KRE8

Tubb2b

Tubulin beta-2B chain

CC, HP

Q4QRB4

Tubb3

Tubulin beta-3 chain

CC, HP, CB

Q9QUL6

Nsf

Vesicle-fusing ATPase

CC, HP, CB

Q62634

Slc17a7

Vesicular glutamate transporter 1

CC, HP

Q9JI12

Slc17a6

Vesicular glutamate transporter 2

CC

O35458

Slc32a1

Vesicular inhibitory amino acid transporter

CC, HP

P62762

Vsnl1

Visinin-like protein 1

CB

Q71RJ2

Cacng2

Voltage-dependent calcium channel gamma-2 subunit

CB

Q6QIX3

Slc30a3

Zinc transporter 3

CC