Table 2 KEGG category enrichment analysis of the neuronal differentiation annotated network obtained using ClueGo plugin of the Cytoscape software. Enriched categories identified are those with p-value < 0.05.
From: Identification and characterization of the BRI2 interactome in the brain
KEGG Term ID | KEGG Term | Nr. Genes | % Associated Genes | pValue | Associated Genes Found |
|---|---|---|---|---|---|
KEGG:04012 | ErbB signaling pathway | 12 | 13.636364 | 1.81E-08 | ABL1, AKT1, CAMK2A, CAMK2B, CDKN1A, EGFR, ERBB4, GRB2, JUN, MYC, NCK1, SRC |
KEGG:05215 | Prostate cancer | 10 | 11.235955 | 4.00E-06 | AKT1, BCL2, CDKN1A, EGFR, GRB2, HSP90AA1, HSP90AB1, IKBKG, MDM2, TP53 |
KEGG:05161 | Hepatitis B | 12 | 8.219178 | 6.07E-06 | AKT1, BCL2, CDKN1A, FOS, GRB2, IKBKG, JUN, MYC, SRC, STAT1, TP53, YWHAQ |
KEGG:05014 | Amyotrophic lateral sclerosis (ALS) | 8 | 15.686275 | 6.07E-06 | BCL2, BID, GRIN1, GRIN2B, NEFL, NEFM, TNFRSF1B, TP53 |
KEGG:04915 | Estrogen signaling pathway | 10 | 10.0 | 1.16E-05 | AKT1, EGFR, ESR2, FOS, GNAO1, GRB2, HSP90AA1, HSP90AB1, JUN, SRC |
KEGG:05169 | Epstein-Barr virus infection | 13 | 6.372549 | 3.20E-05 | AKT1, BCL2, CDKN1A, CSNK2B, IKBKG, JUN, MDM2, MYC, TP53, TRAF6, VIM, YWHAG, YWHAQ |
KEGG:05205 | Proteoglycans in cancer | 13 | 6.3414636 | 3.32E-05 | AKT1, CAMK2A, CAMK2B, CDKN1A, EGFR, ERBB4, GRB2, MDM2, MYC, PPP1CA, SMAD2, SRC, TP53 |
KEGG:05214 | Glioma | 8 | 12.121212 | 4.40E-05 | AKT1, CAMK2A, CAMK2B, CDKN1A, EGFR, GRB2, MDM2, TP53 |
KEGG:04722 | Neurotrophin signaling pathway | 10 | 8.264462 | 6.44E-05 | ABL1, AKT1, BCL2, CAMK2A, CAMK2B, GRB2, JUN, MAP3K3, TP53, TRAF6 |
KEGG:05220 | Chronic myeloid leukemia | 8 | 10.958904 | 9.26E-05 | ABL1, AKT1, CDKN1A, GRB2, IKBKG, MDM2, MYC, TP53 |
KEGG:04728 | Dopaminergic synapse | 10 | 7.6923075 | 1.20E-04 | AKT1, ARRB2, CAMK2A, CAMK2B, FOS, GNAO1, GRIN2B, KIF5A, KIF5C, PPP1CA |
KEGG:05219 | Bladder cancer | 6 | 14.634147 | 3.29E-04 | CDKN1A, EGFR, MDM2, MYC, SRC, TP53 |
KEGG:05210 | Colorectal cancer | 7 | 11.290322 | 3.32E-04 | AKT1, BCL2, FOS, JUN, MYC, SMAD2, TP53 |
KEGG:05031 | Amphetamine addiction | 7 | 10.294118 | 5.92E-04 | CAMK2A, CAMK2B, FOS, GRIN1, GRIN2B, JUN, PPP1CA |
KEGG:04921 | Oxytocin signaling pathway | 10 | 6.289308 | 6.65E-04 | CAMK2A, CAMK2B, CDKN1A, EGFR, FOS, GNAO1, JUN, PPP1CA, RGS2, SRC |
KEGG:04360 | Axon guidance | 10 | 5.681818 | 1.57E-03 | ABL1, CAMK2A, CAMK2B, DPYSL2, FYN, NCK1, RYK, SEMA4F, SEMA6A, SRC |
KEGG:05130 | Pathogenic Escherichia coli infection | 6 | 10.909091 | 1.70E-03 | ABL1, FYN, NCK1, TUBB2B, TUBB3, YWHAQ |
KEGG:05224 | Breast cancer | 9 | 6.1643834 | 2.00E-03 | AKT1, CDKN1A, EGFR, ESR2, FOS, GRB2, JUN, MYC, TP53 |
KEGG:05222 | Small cell lung cancer | 7 | 8.139535 | 2.46E-03 | AKT1, BCL2, IKBKG, MYC, RXRB, TP53, TRAF6 |
KEGG:04721 | Synaptic vesicle cycle | 6 | 9.523809 | 3.40E-03 | RAB3A, RIMS1, SNAP25, STX1B, STXBP1, SYT1 |
KEGG:04110 | Cell cycle | 8 | 6.451613 | 3.53E-03 | ABL1, CDKN1A, MDM2, MYC, SMAD2, TP53, YWHAG, YWHAQ |
KEGG:04912 | GnRH signaling pathway | 7 | 7.6086955 | 3.60E-03 | CAMK2A, CAMK2B, EGFR, GRB2, JUN, MAP3K3, SRC |
KEGG:05212 | Pancreatic cancer | 6 | 9.090909 | 4.12E-03 | AKT1, EGFR, IKBKG, SMAD2, STAT1, TP53 |
KEGG:04713 | Circadian entrainment | 7 | 7.2916665 | 4.34E-03 | CAMK2A, CAMK2B, FOS, GNAO1, GRIN1, GRIN2B, MTNR1A |
KEGG:04380 | Osteoclast differentiation | 8 | 6.060606 | 5.02E-03 | AKT1, FOS, FYN, GRB2, IKBKG, JUN, STAT1, TRAF6 |
KEGG:05160 | Hepatitis C | 8 | 6.0150375 | 5.14E-03 | AKT1, CDKN1A, EGFR, GRB2, IKBKG, STAT1, TP53, TRAF6 |
KEGG:04068 | FoxO signaling pathway | 8 | 5.970149 | 5.25E-03 | AGAP2, AKT1, CDKN1A, EGFR, GABARAPL2, GRB2, MDM2, SMAD2 |
KEGG:04917 | Prolactin signaling pathway | 6 | 8.333333 | 5.77E-03 | AKT1, ESR2, FOS, GRB2, SRC, STAT1 |
KEGG:05142 | Chagas disease (American trypanosomiasis) | 7 | 6.730769 | 6.15E-03 | AKT1, FOS, GNAO1, IKBKG, JUN, SMAD2, TRAF6 |
KEGG:04660 | T cell receptor signaling pathway | 7 | 6.6666665 | 6.31E-03 | AKT1, FOS, FYN, GRB2, IKBKG, JUN, NCK1 |
KEGG:04725 | Cholinergic synapse | 7 | 6.3063064 | 8.59E-03 | AKT1, BCL2, CAMK2A, CAMK2B, FOS, FYN, GNAO1 |
KEGG:05213 | Endometrial cancer | 5 | 9.615385 | 9.08E-03 | AKT1, EGFR, GRB2, MYC, TP53 |
KEGG:04724 | Glutamatergic synapse | 7 | 6.140351 | 9.39E-03 | DLG4, DLGAP1, GNAO1, GRIN1, GRIN2B, SHANK1, SLC1A3 |
KEGG:04919 | Thyroid hormone signaling pathway | 7 | 5.9322033 | 1.11E-02 | AKT1, MDM2, MYC, RXRB, SRC, STAT1, TP53 |
KEGG:05223 | Non-small cell lung cancer | 5 | 8.928572 | 1.14E-02 | AKT1, EGFR, GRB2, RXRB, TP53 |
KEGG:04720 | Long-term potentiation | 5 | 7.4626865 | 2.51E-02 | CAMK2A, CAMK2B, GRIN1, GRIN2B, PPP1CA |
KEGG:04066 | HIF-1 signaling pathway | 6 | 5.8252425 | 2.68E-02 | AKT1, BCL2, CAMK2A, CAMK2B, CDKN1A, EGFR |
KEGG:04210 | Apoptosis | 7 | 5.0 | 2.71E-02 | AKT1, BCL2, BID, FOS, IKBKG, JUN, TP53 |
KEGG:04620 | Toll-like receptor signaling pathway | 6 | 5.6603775 | 2.81E-02 | AKT1, FOS, IKBKG, JUN, STAT1, TRAF6 |
KEGG:05218 | Melanoma | 5 | 7.0422535 | 2.83E-02 | AKT1, CDKN1A, EGFR, MDM2, TP53 |
KEGG:04662 | B cell receptor signaling pathway | 5 | 6.849315 | 2.89E-02 | AKT1, FOS, GRB2, IKBKG, JUN |
KEGG:04520 | Adherens junction | 5 | 6.756757 | 2.90E-02 | CSNK2B, EGFR, FYN, SMAD2, SRC |
KEGG:05145 | Toxoplasmosis | 6 | 5.084746 | 3.83E-02 | AKT1, BCL2, GNAO1, IKBKG, STAT1, TRAF6 |
KEGG:05030 | Cocaine addiction | 4 | 8.163265 | 4.04E-02 | DLG4, GRIN1, GRIN2B, JUN |
