Figure 4 | Scientific Reports

Figure 4

From: Alternative splicing of ALCAM enables tunable regulation of cell-cell adhesion through differential proteolysis

Figure 4

Alternative splicing of ALCAM diminishes ALCAM-ALCAM adhesion. (a) Representative images of ALCAM-KO HT1080 cells (KO) expressing ALCAM-Iso1 (KO + Iso1) or ALCAM-Iso2 (KO + Iso2) adhered to immobilized ALCAM-Fc. (b) Cells attached to ALCAM-Fc were stained with crystal violet dye. Percent of cells attached at 4 hours was quantified compared to cells attached to collagen type I coated wells. P-values were calculated using Kruskal-Wallis test with Dunn’s post-test, ***P < 0.001, ****P < 0.0001.

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