Figure 1 | Scientific Reports

Figure 1

From: A Genetic Screen for Investigating the Human Lysosomal CystineTransporter, Cystinosin

Figure 1

Schematic figure showing how a heterologously expressed CTNS and CTNS-Δgydql could confer growth on cystine in an S. cerevisiae met15Δ strain. Heterologous expression of CTNS in S. cerevisiae is expected to cause its intracellular retention, whereas expression of CTNS-Δgydql (lacking C-terminal lysosomal targeting motif) possibly misdirects the protein to the plasma membrane leading to cystine intake from the extracellular milleu.

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