Table 1 Imaging and Clinico-Pathological Factors between Patients with and without Residual ALN metastases after Neoadjuvant Chemotherapy.

From: Prediction of Advanced Axillary Lymph Node Metastases (ypN2-3) Using Breast MR imaging and PET/CT after Neoadjuvant Chemotherapy in Invasive Ductal Carcinoma Patients

Characteristics

Patients without Residual ALN metastases (n = 59)

Patients with Residual ALN metastases (n = 49)

P Value

Age, years*

45.2 ± 8.3

47.8 ± 8.5

0.110

Initial clinical T stages

Ā Ā 

0.425

Ā Ā T1

7 (11.9%)

6 (12.2%)

Ā 

Ā Ā T2

39 (66.1%)

29 (59.2%)

Ā 

Ā Ā T3

11 (18.6%)

10 (20.4%)

Ā 

Ā Ā T4

2 (3.4%)

4 (8.2%)

Ā 

Initial clinical N stages

Ā Ā 

0.162

Ā Ā N0

4 (6.8%)

2 (4.1%)

Ā 

Ā Ā N1

26 (44.1%)

16 (32.7%)

Ā 

Ā Ā N2

22 (37.3%)

23 (46.9%)

Ā 

Ā Ā N3

7 (11.9%)

8 (16.3%)

Ā 

Histologic grade

Ā Ā 

0.208

Ā Ā Low to moderate

42 (71.2%)

40 (81.6%)

Ā 

Ā Ā High

17 (28.8%)

9 (18.4)

Ā 

HR status

Ā Ā 

0.011

Ā Ā Negative

30 (50.8%)

13 (26.5%)

Ā 

Ā Ā Positive

29 (49.2%)

36 (73.5%)

Ā 

HER2 status

Ā Ā 

0.046

Ā Ā Negative

31 (47.0%)

35 (71.4%)

Ā 

Ā Ā Positive

28 (66.7%)

14 (28.6%)

Ā 

Number of positive ALNs on initial staging MR imaging**

Ā Ā 

0.032

Ā Ā <7

51 (86.4%)

34 (69.4%)

Ā 

  ≄7

8 (13.6%)

15 (30.6%)

Ā 

Number of positive ALNs on restaging MR imaging**

Ā Ā 

0.001

Ā Ā 0

43 (72.9%)

20 (40.8%)

Ā 

  ≄1

16 (27.1%)

29 (59.2%)

Ā 

Short diameter of the largest ALN on initial staging MR imaging

Ā Ā 

0.015

  ≤18.0 mm

56 (94.9%)

39 (79.6%)

Ā 

Ā Ā >18.0 mm

3 (5.1%)

10 (20.4%)

Ā 

Short diameter of the largest ALN on restaging MR imaging

Ā Ā 

0.296

  ≤6.8 mm

44 (74.6%)

32 (65.3%)

Ā 

Ā Ā >6.8 mm

15 (25.4%)

17 (34.7%)

Ā 

Nodal SUVmax on initial staging PET/CT

Ā Ā 

0.053

  ≤6.4

42 (71.2%)

26 (53.1%)

Ā 

Ā Ā >6.4

17 (28.8%)

23 (46.9%)

Ā 

Nodal SUVmax on restaging PET/CT

Ā Ā 

0.012

  ≤0.9

59 (100%)

44 (89.8%)

Ā 

Ā Ā >0.9

0

5 (10.2%)

Ā 
  1. HR = hormone receptor; HER2 = human epidermal growth factor receptor 2; ALN = axillary lymph node; SUVmax = maximal standardized uptake value.
  2. Data are the numbers of patients, with percentages in parentheses unless otherwise indicated by an asterisk.
  3. *Data are mean ± standard deviation.
  4. **The positive axillary LN was considered when one or more findings were noted as follows: cortical thickness >3 mm, eccentric cortical thickening, loss of fatty hilum, and round or lobulated nodal shape at MR imaging.