Table 3 Imaging and Clinico-Pathological Factors between Patients with and without Advanced ALN metastases after Neoadjuvant Chemotherapy.

From: Prediction of Advanced Axillary Lymph Node Metastases (ypN2-3) Using Breast MR imaging and PET/CT after Neoadjuvant Chemotherapy in Invasive Ductal Carcinoma Patients

Characteristics

Patients without Advanced ALN metastases (n = 96)

Patients with Advanced ALN metastases (n = 12)

P Value

Age, years*

46.2 ± 8.5

48.3 ± 7.9

0.421

Initial clinical T stages

Ā Ā 

0.230

Ā Ā T1

13 (13.5%)

0

Ā 

Ā Ā T2

60 (62.5%)

8 (66.7%)

Ā 

Ā Ā T3

18 (18.8%)

3 (25.0%)

Ā 

Ā Ā T4

5 (5.2%)

1 (8.3%)

Ā 

Initial clinical N stages

Ā Ā 

0.195

Ā Ā N0

6 (6.2%)

0

Ā 

Ā Ā N1

38 (39.6%)

4 (33.3%)

Ā 

Ā Ā N2

40 (41.7%)

5 (41.7%)

Ā 

Ā Ā N3

12 (12.5%)

3 (25.0%)

Ā 

Histologic grade

Ā Ā 

0.937

Ā Ā Low to moderate

73 (76.0%)

9 (75.0%)

Ā 

Ā Ā High

23 (24.0%)

3 (25.0%)

Ā 

HR status

Ā Ā 

0.890

Ā Ā Negative

38 (39.6%)

5 (41.7%)

Ā 

Ā Ā Positive

58 (60.4%)

7 (58.3%)

Ā 

HER2 status

Ā Ā 

0.677

Ā Ā Negative

58 (60.4%)

8 (66.7%)

Ā 

Ā Ā Positive

38 (39.6%)

4 (33.3%)

Ā 

Number of positive ALNs on initial staging MR imaging**

Ā Ā 

0.015

Ā Ā <4

52 (54.2%)

2 (16.7%)

Ā 

  ≄4

44 (45.8%)

10 (83.3%)

Ā 

Number of positive ALNs on restaging MR imaging**

Ā Ā 

<0.001

Ā Ā <2

86 (89.6%)

5 (41.7%)

Ā 

  ≄2

10 (10.4%)

7 (58.3%)

Ā 

Short diameter of the largest ALN on initial staging MR imaging

Ā Ā 

0.295

  ≤ 7.7 mm

26 (27.1%)

5 (41.7%)

Ā 

Ā Ā >7.7 mm

70 (72.9%)

7 (58.3%)

Ā 

Short diameter of the largest ALN on restaging MR imaging

Ā Ā 

0.007

  ≤7.7 mm

80 (83.3%)

6 (50.0%)

Ā 

Ā Ā >7.7 mm

16 (16.7%)

6 (50.0%)

Ā 

Nodal SUVmax on initial staging PET/CT

Ā Ā 

0.060

  ≤2.6

34 (35.4%)

1 (8.3%)

Ā 

Ā Ā >2.6

62 (64.6%)

11 (91.7%)

Ā 

Nodal SUVmax on restaging PET/CT

Ā Ā 

<0.001

  ≤1.1

84 (87.5%)

5 (41.7%)

Ā 

Ā Ā >1.1

12 (12.5%)

7 (58.3%)

Ā 
  1. HR = hormone receptor; HER2 = human epidermal growth factor receptor 2; ALN = axillary lymph node; SUVmax = maximal standardized uptake value.
  2. Data are numbers of patients, with percentages in parentheses unless otherwise indicated by an asterisk.
  3. *Data are mean ± standard deviation.
  4. **The positive axillary LN was considered when one or more findings were noted as follows: cortical thickness>3 mm, eccentric cortical thickening, loss of fatty hilum, and round or lobulated nodal shape at MR imaging.