Table 3 Genotypic association analysis between rs4642101, rs6584555, rs13216675 and rs6490029 and AF under three different genetic models.

From: Genomic Variants in NEURL, GJA1 and CUX2 Significantly Increase Genetic Susceptibility to Atrial Fibrillation

Model*

Genotypes (AA/AB/BB)

Without Adjustment

Adjustment

Bonferroni correction

Cases

Controls

P obs

OR (95%CI)

P adj

OR (95%CI)

P

rs4642101

Additive

502/392/95

620/449/100

0.49

n.a

0.18

0.91 (0.8–1.04)

0.55

Dominant

502/487

620/549

0.29

1.10 (0.93–1.30)

0.26

0.9 (0.76–1.1)

0.70

Recessive

894/95

1069/100

0.35

1.14 (0.86–1.53)

0.27

0.85 (0.62–1.14)

0.72

rs13216675

Additive

124/471/460

177/476/430

6.72 × 10–3

n.a

0.01

1.19 (1.04–1.35)

0.04

Dominant

124/931

177/906

2.28 × 10−3

1.47 (1.15–1.88)

3.04 × 10−3

1.49 (1.14–1.92)

0.01

Recessive

595/460

653/430

0.07

1.17 (0.99–1.4)

0.14

0.87 (0.72–1.05)

0.45

rs6584555

Additive

737/294/50

952/290/32

4.03 × 10−4

n.a

4.85 × 10−5

1.41 (1.19–1.67)

1.94 × 10−4

Dominant

737/344

952/322

4.38 × 10−4

1.38 (1.15–1.65)

4.26 × 10−4

1.43 (1.16–1.72)

1.70 × 10−3

Recessive

1031/50

1242/32

5.3 × 10−3

1.89 (1.2–2.96)

1.51 × 10−3

2.32 (1.37–3.85)

6.03 × 10−3

rs6490029

Additive

58/412/530

97/423/578

0.02

n.a

0.54

0.96 (0.83–1.1)

0.95

Dominant

58/942

97/1001

7.97 × 10−3

1.57(1.12–2.2)

8.28 × 10−3

1.61(1.12–2.27)

0.04

Recessive

470/530

520/578

0.87

1.01(0.86–1.2)

0.65

1.04 (0.87–1.25)

0.96

  1. *Additive model = AA/AB/BB; dominant model = AA + AB/BB; recessive model = AA/AB + BB;
  2. P obs , P value for association before adjusting for covariates by 2 × 2 contingence table χ2 test using PLINK version 1.07;
  3. P adj , P value for association after adjusting for covariates of sex, age, HTN, CAD and DM by multiple logistic regression analysis using SPSS v17.0;
  4. OR, odds ratio;
  5. 95% CI, 95% confidential interval.
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