Figure 4
From: A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK
Identification of new PanK inhibitors. (A) IC50 determination against PanK for CDD-823953 (▼), CDD-934506 (●) and GSK-735826A (■). (B) Global reciprocal plot of steady state kinetics analysis towards ATP of PanK in the presence GSK-735826 compound, highlight the competitive nature of the inhibition.
