Table 2 GSK and CDD compound structures with PyrG and PanK activities.
From: A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK
Compounds | Identifier | PyrG IC50 (μM) | PanK IC50 (μM) | MIC (μM) | LibDock score |
|---|---|---|---|---|---|
| GSK1570606A | 4.2 | n. i. | 9.3 | 104.59 |
| GSK735826A | 22 | 70 | 2.7 | 94.69 |
| GSK920684A | 22 | n. i. | 3.5 | 106.90 |
| CDD-934506 | n. i. | 40 | 0.87 | 121.81 |
| CDD-823953 | 80 | 250 | 4.39 | 116.15 |
