Figure 5
PK resistance of Aβ-containing human brain extracts. Insoluble fractions from AD brain homogenates were digested with 0, 25, 50, 100 µg/ml of PK and analyzed by Western blot using 4G8 antibody. The signal intensity of all the Aβ aggregates (a,b) or of Aβ dimers (a,c) was quantified by densitometry; data were compared by two-ways ANOVA (*p < 0.05; ***p < 0.001). Each blot shows the digestion of one brain extract representative of each amyloid profile. The blots were cropped; the original blots are shown in Supplementary Figure S3.
