Table 2 Selected features for prediction of targetable pathways.
Pathway | Clinical features | Global variables | Histogram-based features | Lung cancer-specific features | Shape features | Local features | Regional features | Emphysema features | |
|---|---|---|---|---|---|---|---|---|---|
Redox stress | Variables | Volume | Energy | Maximum 3D diameter | Cluster prominence | Size-zone variability | |||
Odds ratio (95% CI) | 1.64 (0.32–8.30) | 0.15 (0.02–1.05) | 0.88 (0.20–3.82) | 1.28 (0.64–2.56) | 2.16 (0.66–7.06) | ||||
p value | 0.55 | 0.06 | 0.86 | 0.49 | 0.20 | ||||
Apoptosis | Variables | Mass | Range | Maximum 3D diameter | Cluster shade | Intensity variability | |||
Odds ratio (95% CI) | 23.94 (0.54- > 999.99) | 0.08 (0.01–0.82) | 2.06 (0.16–26.46) | 0.69 (0.13–3.80) | 0.35 (0.06–2.26) | ||||
p value | 0.10 | 0.03 | 0.58 | 0.67 | 0.27 | ||||
Proliferation | Variables | HU at the 97.5th percentile | MPP | Cluster prominence | Right lung volume | ||||
Odds ratio (95% CI) | 1.83 (0.69–8.61) | 1.33 (0.23–7.56) | 1.77 (0.82–3.81) | 0.35 (0.13–0.90) | |||||
p value | 0.44 | 0.75 | 0.15 | 0.03 | |||||
Differentiation | Variables | Smoking pack-years | Minimum | Spherical disproportion | Intensity variability | ||||
Odds ratio (95% CI) | 1.01 (0.99–1.04) | 1.21 (0.59–2.47) | 0.68 (0.33–1.43) | 0.73 (0.32–1.68) | |||||
p value | 0.26 | 0.60 | 0.31 | 0.46 | |||||
Chromatin remodelers | Variables | Smoking pack-years | Energy | Maximum probability | |||||
Odds ratio (95% CI) | 1.02 (0.99–1.04) | 1.73 (0.94–3.19) | 0.54 (0.28–1.05) | ||||||
p value | 0.11 | 0.08 | 0.07 |
