Figure 3
Vangl2Lp/+ mutation is associated with regionally smaller cortical bone mass in the tibia of young male mice. SSA µCT analysis of cortical bone structure at each 1% site along the bone’s length in 3-week-old male Vangl2+/+ and Vangl2Lp/+ littermates (n = 8 each). The tibia image indicates the orientation of SSA (proximal at 0% to distal at 100%). The tibia/fibula junction is indicated by the dashed vertical line (the fibula is automatically excluded from SSA). (A) Ct.Ar, (B) Tt.Ar, (C) Ma.Ar, (D) Cs.Th, (E) PMI and (F) eccentricity were quantified. (C’) Magnified view of marrow area quantification in the distal tibia. Green lines indicate regions of significant differences between genotypes by mixed model analysis with Bonferroni post-hoc.
