Figure 5
From: Hypoxia-induced long non-coding RNA Malat1 is dispensable for renal ischemia/reperfusion-injury
Inflammatory gene expression and cell influx upon unilateral renal I/Rinjury. Il-1b (A). MIP2a (B), Il-6 (C) and MCP-1 expression (D) in ischemic murine kidneys. Analysis of F4/80 (red) positive macrophage infiltration in wildtype control (E), knockout control (F), wildtype with ischemia/reperfusion injury (G) and knockout mice with ischemia/reperfusion injury (H) as well as quantification of the results (I) at 7 days of reperfusion. Analysis of CD3 (red) positive T-cell infiltration in wildtype control (J), knockout control (K), wildtype with ischemia/reperfusion injury (L) and knockout mice with ischemia/reperfusion injury (M) as well as quantification of results (N) at 7 days of reperfusion. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001; n = 6 mice in each group. Il-1b = Interleukin-1beta, MIP2a = Macrophage inflammatory protein-2 alpha; Il-6 = Interleukin-6; MCP-1 = monocyte chemoattractant protein – 1, KO = knockout, WT = wildtype, CTL = control, I/R = ischemia/reperfusion-injury, FC = foldchange.
