Figure 5
Clustered heatmaps of significantly changed genes in Tg1MDW/1MDW Affymetrix microarray analysis. (A) OC-P5 heatmap showing normalized expression for 32 significantly changed genes found by two-way ANOVA (Age X Genotype, FDR-adjusted P < 0.05, fold change cutoff ± 2). (B) Cochlear-P18 heatmap of normalized expression for 52 probesets (45 genes) significantly changed in Tg1MDW/1MDW (FDR-adjusted P < 0.05, fold change cutoff ±2). Irrespective of age, the most upregulated Affymetrix probesets were genetic elements of Tg1MDW: Mir183, Mir96, Mir182 and Prm1 (boxed probesets).
