Figure 9 | Scientific Reports

Figure 9

From: Rational Design, Synthesis and Biological Evaluation of Pyrimidine-4,6-diamine derivatives as Type-II inhibitors of FLT3 Selective Against c-KIT

Figure 9

FLT3 inhibition kinetics with compound 13a. Pre-incubation with 13a causes a statistically significant increase in FLT3 inhibition (p < 0.05). An increase in ATP concentration does not cause a statistical significant increase in the FLT3 IC50 value (p > 0.05). Taken together, incubation kinetics suggest 13a is non-competitive, Type-II kinase inhibitor.

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