Table 5 Cell-based inhibitory activity of compounds 13a, 13b, 13d, 13k, 13r, 13v, and 13ag in FLT3-driven cell lines.

From: Rational Design, Synthesis and Biological Evaluation of Pyrimidine-4,6-diamine derivatives as Type-II inhibitors of FLT3 Selective Against c-KIT

Cell Line

GI50 (nM)

13a

13b

13d

13k

13r

13v

13ag

Ba/F3 FLT3-ITD

131.3

158.5

/

40.5

266.4

>10000

4013

Molm14 par

24.4

186.7

/

19.8

186.7

>10000

1826

Molm14D835Y

1842

2226

/

2609

2226

>10000

/

Molm14F691L

1345

1346

/

2142

1346

>10000

/

MV4–11

9.9

80.6

2251

7.2

80.6

>10000

527

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