Figure 3
From: Ablation of Bax and Bak protects skeletal muscle against pressure-induced injury
Pressure-induced inflammation in skeletal muscle is mediated by apoptosis. (a) to (b) show the comparison of animals (WT, Bak−/−, Baxfl/flBak−/−, and Bax−/−Bak−/− mice in this order) for (a) myeloperoxidase (MPO) activity (n = 6 mice/group), and (b) lactate dehydrogenase (LDH) activity (n = 6 mice/group) in control (“−” or clear bars) and compressed (“+” or shaded black bars) muscle tissues. All values are expressed as means ± standard error of mean. Pairwise comparison was performed with Student’s t-test, *P < 0.05, **P < 0.01. One-wayanalysis of variance (ANOVA) and Tukey’s post hoc test were used to compare multiple groups, ##P < 0.01. (c) The detection of neutrophil elastase activities after mechanical compression by in vivo fluorescence imaging (n = 3 mice/group).
