Figure 1
From: Foxm1 controls a pro-stemness microRNA network in neural stem cells
Foxm1 levels upon modulation of the Hedgehog pathway. (A) Hierarchical clustering of the 988 transcripts differentially expressed (adj. P < 0.05) (Bray-Curtis method with average linkage). (B) RT-qPCR data showing Gli1 and Foxm1 levels in mouse NSCs before and after 48 h of cyclopamine-KAAD (KAAD) treatment. P values vs. CTRL (DMSO as control) (*P < 0.05: 0.0412, **P < 0.01: 0.0044). (Mann–Whitney U test). (C) RT-qPCR data showing GLI1 and FOXM1 levels in normal human neural progenitors (NHNP) before and after 48 h of cyclopamine-KAAD (KAAD) treatment. P values vs. CTRL (DMSO as control). (*P < 0.05: 0.02, **P < 0.01: 0.0031). (Mann–Whitney U test). Bars in B and C represent the mean (SD) of three independent experiments.
