Figure 5 | Scientific Reports

Figure 5

From: Magnetic Resonance Imaging of Atherosclerotic Plaque at Clinically Relevant Field Strengths (1T) by Targeting the Integrin α4β1

Figure 5

In vivo MRI of atherosclerotic plaques. (A) Timeline for MRI studies. ApoE−/− mice (12–14 weeks old) were fed a high-fat diet (HFD) for ~10 weeks before initiating the start of imaging. MRI was performed at 3 time points: (1) precontrast, (2) immediate postcontrast (within 1 hour of contrast administration to acquire an angiogram of the aorta), and (3) delayed postcontrast at 72 h after contrast administration. (B) Representative coronal T1-weighted pseudo-colored MR images of the aortic arch from a THI0567-targeted liposomal-Gd treated mouse (top row) and a non-targeted liposomal-Gd-treated mouse (bottom row) at baseline, immediate postcontrast, and delayed postcontrast. Signal enhancement within the aortic arch wall in a THI0567-targeted liposomal-Gd-treated mouse (red arrow) is shown. (C) Representative coronal T1-weighted pseudo-colored MR images of the descending aorta from a THI0567-targeted liposomal-Gd-treated mouse (top row) and a non-targeted liposomal-Gd treated-mouse (bottom row). Signal enhancement is seen in the aortic wall in the THI0567-targeted liposomal-Gd treated mouse (red arrows).

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