Figure 6 | Scientific Reports

Figure 6

From: Magnetic Resonance Imaging of Atherosclerotic Plaque at Clinically Relevant Field Strengths (1T) by Targeting the Integrin α4β1

Figure 6

Quantitative analysis of MRI signal enhancement in atherosclerotic plaques. (A) Comparison of the normalized enhancement ratio (NER) of atherosclerotic plaques in non-targeted (n = 7) and THI0567-targeted groups of mice (n = 9). Data are presented as average ± SEM. (B) Volume-rendered 3D image of a mouse aorta showing the different aortic segments examined. (C) Comparison of the NER in atherosclerotic plaques in non-targeted (n = 7) and targeted groups of mice (n = 6–8) for different segments of the aorta. Data are presented as average ± SEM. (D,E) Representative sections of oil red staining (upper panels) and Rhodamine B fluorescence (lower panels) from the ascending aorta (D) and aortic arch (E) regions of untreated, THI0567-targeted liposomal-Gd, or non-targeted liposomal-Gd injected mice.

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