Figure 7
THI0567-targeted liposomal-Gd accumulation in atherosclerotic plaques of ApoE−/− mice. (A) Confocal fluorescence imaging of histological sections of the aortic root from mice injected with THI0567-targeted liposomal-Gd (Rhodamine B fluorescence). Control IgG staining is represented in the low magnification (10x) image of the aortic root (upper left panel). Other representative sections were stained with anti-CD31 (upper right), anti-F4/80 (lower right), or anti-CD11b (lower left). Nuclei were stained with Hoechst 33342. (B) Partial section through the aortic arch, including the brachiocephalic artery, stained with anti-CD11b and Hoechst 33342. (C) Confocal fluorescence imaging of aortic arch sections of THI0567-targeted liposomal-Gd treated animals (representative sections from n = 8. Fluorescence: THI0567-targeted liposomal-Gd (Rhodamine B); CD11b (green); CD31 (purple); nuclei (Hoechst 33342; blue).
