Figure 3

Few retinal ganglion cells and no starburst amacrine cells were left after maternal ZIKV infection. (a) P14 retinal Calretinin immunostaining. (b) Percentage of Calretinin-positive cells in the GCL. n^Mock = 7, n^ZIKV = 5, n^DENV-2 = 8 samples from three independent experiments. Data are presented as the mean ± SEM. One-way ANOVA with Bonferroni’s post hoc test, ***p < 0.001. (c) P14 retinal ChAT immunostaining. (d,e) Schematic depiction of a normal retina in mock- or DENV-2 infected mice (d) or a pathological retina in ZIKV-infected mice (e).