Figure 4
Angiotensin II selectively inhibits CaV3.2 channel in cerebral myocytes. (A) Representative traces and average I-V plots showing the effect of Ang II (100 nM) on the residual Ni2+-insensitive T-type current (n = 8). (B) Summary data highlighting the inability of Ang II to inhibit the peak T-type current (pA/pF) in cells treated with Ni2+ (CaV3.2 blocker, 50 µM) (n = 8). (C) T-type current (Imax, pA/pF) suppression by Ang II in the absence (top, n = 8) and presence (bottom, n = 6) of Ni2+. (D) Left bar graph illustrate change in peak T-type current (5 min time intervals) under control conditions (n = 8) or in presence of Ang II ± Ni2+ (n = 6–8); right bar graph displays % inhibition of the T-type current. *Denotes significant difference compared to control (*P < 0.05, paired t test).
