Table 4 Relationships between FREE2 DNA methylation for each CpG unit and FSIQ in males with FXS.

From: Intragenic DNA methylation in buccal epithelial cells and intellectual functioning in a paediatric cohort of males with fragile X

MOR

FSIQa

dFSIQb

cFSIQc

n

β

s.e

p

n

β

s.e

p

n

β

s.e

p

CpG1

11

−11.90

20.14

0.618

25

−32.25

5.87

3.5 × 10−5

25

−63.22

7.23

6.5 × 10−8

CpG2

11

−15.07

19.22

0.618

25

−30.80

7.06

2.5 × 10−5

25

−64.80

8.34

2.4 × 10−7

CpG6/7

10

−15.32

29.53

0.618

24

−38.09

6.02

1.2 × 10−5

24

−68.39

11.72

1.1 × 10−5

CpG8/9

12

−28.81

12.38

0.210

25

−32.50

8.87

1.0 × 10−3

25

−66.57

13.36

5.5 × 10−5

CpG10-12

11

−11.41

21.85

0.618

25

−33.60

7.55

2.5 × 10−4

25

−70.00

9.27

2.5 × 10−7

  1. Abbreviation: FSIQ = standardized FSIQ; dFSIQ = Standardized + default FSIQ; cFSIQ = FSIQ corrected with the Whitaker and Gordon method; MOR, methylation output ratio; analyses conducted: aLinear regression unadjusted for age; bRobust regression unadjusted for age; cRobust regression adjusted for age; β, estimated regression coefficient; s.e., standard error. Note: all p-values reported are adjusted for multiple testing (FDR); p-values less than 0.05 are highlighted in bold.
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