Figure 2
From: The efficacy of Ranolazine on E1784K is altered by temperature and calcium
Ranolazine docked to NaV1.5-NaVPas. The side view of NaV1.5-NaVPas homology model is shown docked to Ranolazine. The enlarged inset shows the cartoon structure of the drug binding to the central domains of the channel. The aromatic F1760 residue is outlined. Below the inset is a 3D-structure of Ranolazine (Nitrogen is blue, Oxygen is red, Carbon is green, and Hydrogen is grey). Conserved residues in DIII-DIV linker and CTD between NaV1.5 and NaVPas are indicated by a red asterisk.
