Table 1 Peak INa Current and Conductance Density.
From: The efficacy of Ranolazine on E1784K is altered by temperature and calcium
Condition | Peak INa Density (pA/pF) | N | Peak GV Density (nS/pF) | N |
|---|---|---|---|---|
WT - 22 °C - 0 nM Ca2+ - 0 µM Ran | 148.97 ± 35.10 | 7 | 2348.13 ± 584.87 | 7 |
WT - 22 °C - 0 nM Ca2+ - 10 µM Ran | 241.31 ± 41.80 | 5 | 3708.29 ± 580.79 | 5 |
WT - 22 °C - 0 nM Ca2+ - 100 µM Ran | 184.16 ± 40.16 | 5 | 3030.10 ± 640.76 | 5 |
WT - 22 °C - 2500 nM Ca2+ - 0 µM Ran | 302.91 ± 59.07 | 9 | 4714.99 ± 971.64 | 9 |
WT - 22 °C - 2500 nM Ca2+ - 10 µM Ran | 250.88 ± 45.34 | 7 | 4599.97 ± 788.18 | 7 |
WT - 22 °C - 2500 nM Ca2+ - 100 µM Ran | 128.74 ± 34.69 | 9 | 2088.79 ± 517.47 | 9 |
WT - 34 °C - 0 nM Ca2+ - 0 µM Ran | 354.74 ± 83.12 | 7 | 6067.75 ± 1197.96 | 6 |
WT - 34 °C - 0 nM Ca2+ - 10 µM Ran | 472.24 ± 55.47 | 5 | 7370.72 ± 654.58 | 7 |
WT - 34 °C - 0 nM Ca2+ - 100 µM Ran | 369.56 ± 81.13 | 8 | 5321.49 ± 1074.25 | 8 |
WT - 34 °C - 2500 nM Ca2+ - 0 µM Ran | 535.63 ± 70.44 | 6 | 7979.56 ± 433.11 | 5 |
WT - 34 °C - 2500 nM Ca2+ - 10 µM Ran | 447.46 ± 106.69 | 6 | 5948.51 ± 1253.7 | 6 |
WT - 34 °C - 2500 nM Ca2+ - 100 µM Ran | 599.72 ± 113.81 | 6 | 6935.36 ± 1048.34 | 5 |
EK - 22 °C - 0 nM Ca2+ - 0 µM Ran | 214.56 ± 50.18 | 7 | 3762.09 ± 835.36 | 7 |
EK - 22 °C - 0 nM Ca2+ - 10 µM Ran | 265.65 ± 51.36 | 8 | 4534.15 ± 651.10 | 10 |
EK - 22 °C - 0 nM Ca2+ - 100 µM Ran | 240.86 ± 24.43 | 7 | 3576.84 ± 301.37 | 7 |
EK - 22 °C - 2500 nM Ca2+ - 0 µM Ran | 170.41 ± 31.44 | 5 | 3660.43 ± 1006.25 | 6 |
EK - 22 °C - 2500 nM Ca2+ - 10 µM Ran | 250.36 ± 33.96 | 6 | 4562.87 ± 453.93 | 8 |
EK - 22 °C - 2500 nM Ca2+ - 100 µM Ran | 183.02 ± 44.18 | 5 | 2886.72 ± 498.80 | 5 |
EK - 34 °C - 0 nM Ca2+ - 0 µM Ran | 257.99 ± 34.07 | 8 | 3613.63 ± 524.71 | 9 |
EK - 34 °C - 0 nM Ca2+ - 10 µM Ran | 322.26 ± 47.45 | 6 | 5422.63 ± 833.24 | 8 |
EK - 34 °C - 0 nM Ca2+ - 100 µM Ran | 278.25 ± 67.75 | 8 | 4834.84 ± 766.20 | 7 |
EK - 34 °C - 2500 nM Ca2+ - 0 µM Ran | 354.25 ± 64.03 | 8 | 5587.74 ± 831.96 | 7 |
EK - 34 °C - 2500 nM Ca2+ - 10 µM Ran | 227.98 ± 41.82 | 5 | 3154.90 ± 685.41 | 5 |
EK - 34 °C - 2500 nM Ca2+ - 100 µM Ran | 212.41 ± 28.73 | 9 | 2959.51 ± 471.73 | 9 |