Table 1 Peak INa Current and Conductance Density.

From: The efficacy of Ranolazine on E1784K is altered by temperature and calcium

Condition

Peak INa Density (pA/pF)

N

Peak GV Density (nS/pF)

N

WT - 22 °C - 0 nM Ca2+ - 0 µM Ran

148.97 ± 35.10

7

2348.13 ± 584.87

7

WT - 22 °C - 0 nM Ca2+ - 10 µM Ran

241.31 ± 41.80

5

3708.29 ± 580.79

5

WT - 22 °C - 0 nM Ca2+ - 100 µM Ran

184.16 ± 40.16

5

3030.10 ± 640.76

5

WT - 22 °C - 2500 nM Ca2+ - 0 µM Ran

302.91 ± 59.07

9

4714.99 ± 971.64

9

WT - 22 °C - 2500 nM Ca2+ - 10 µM Ran

250.88 ± 45.34

7

4599.97 ± 788.18

7

WT - 22 °C - 2500 nM Ca2+ - 100 µM Ran

128.74 ± 34.69

9

2088.79 ± 517.47

9

WT - 34 °C - 0 nM Ca2+ - 0 µM Ran

354.74 ± 83.12

7

6067.75 ± 1197.96

6

WT - 34 °C - 0 nM Ca2+ - 10 µM Ran

472.24 ± 55.47

5

7370.72 ± 654.58

7

WT - 34 °C - 0 nM Ca2+ - 100 µM Ran

369.56 ± 81.13

8

5321.49 ± 1074.25

8

WT - 34 °C - 2500 nM Ca2+ - 0 µM Ran

535.63 ± 70.44

6

7979.56 ± 433.11

5

WT - 34 °C - 2500 nM Ca2+ - 10 µM Ran

447.46 ± 106.69

6

5948.51 ± 1253.7

6

WT - 34 °C - 2500 nM Ca2+ - 100 µM Ran

599.72 ± 113.81

6

6935.36 ± 1048.34

5

EK - 22 °C - 0 nM Ca2+ - 0 µM Ran

214.56 ± 50.18

7

3762.09 ± 835.36

7

EK - 22 °C - 0 nM Ca2+ - 10 µM Ran

265.65 ± 51.36

8

4534.15 ± 651.10

10

EK - 22 °C - 0 nM Ca2+ - 100 µM Ran

240.86 ± 24.43

7

3576.84 ± 301.37

7

EK - 22 °C - 2500 nM Ca2+ - 0 µM Ran

170.41 ± 31.44

5

3660.43 ± 1006.25

6

EK - 22 °C - 2500 nM Ca2+ - 10 µM Ran

250.36 ± 33.96

6

4562.87 ± 453.93

8

EK - 22 °C - 2500 nM Ca2+ - 100 µM Ran

183.02 ± 44.18

5

2886.72 ± 498.80

5

EK - 34 °C - 0 nM Ca2+ - 0 µM Ran

257.99 ± 34.07

8

3613.63 ± 524.71

9

EK - 34 °C - 0 nM Ca2+ - 10 µM Ran

322.26 ± 47.45

6

5422.63 ± 833.24

8

EK - 34 °C - 0 nM Ca2+ - 100 µM Ran

278.25 ± 67.75

8

4834.84 ± 766.20

7

EK - 34 °C - 2500 nM Ca2+ - 0 µM Ran

354.25 ± 64.03

8

5587.74 ± 831.96

7

EK - 34 °C - 2500 nM Ca2+ - 10 µM Ran

227.98 ± 41.82

5

3154.90 ± 685.41

5

EK - 34 °C - 2500 nM Ca2+ - 100 µM Ran

212.41 ± 28.73

9

2959.51 ± 471.73

9