Table 6 Values at 37 °C and 41 °C based on Q₁₀ and Arrhenius Calculations.

From: The efficacy of Ranolazine on E1784K is altered by temperature and calcium

Condition	37 °C (Q ₁₀ )	41 °C (Q ₁₀ )	37 °C (Arrhenius)	41 °C (Arrhenius)
Peak GV Density (nS/pF)
WT - 0 nM Ca²⁺ - 0 µM Ran	16179.18	55592.62	8124.68	10881.05
WT - 0 nM Ca²⁺ - 10 µM Ran	22678.58	99329.99	9107.70	11251.36
WT - 2500 nM Ca²⁺ - 0 µM Ran	27586.50	131656.89	9377.01	11024.82
WT - 2500 nM Ca²⁺ - 10 µM Ran	15043.82	48489.81	6439.00	6969.03
EK - 0 nM Ca²⁺ - 0 µM Ran	3575.20	3527.30	3569.09	3525.15
EK - 0 nM Ca²⁺ - 10 µM Ran	12400.15	35482.80	5731.14	6055.55
EK - 2500 nM Ca²⁺ - 0 µM Ran	14940.82	51538.73	6366.24	7251.15
EK - 2500 nM Ca²⁺ - 10 µM Ran	2860.49	2527.87	2816.21	2513.95
Peak I _Na Density (pA/pF)
WT - 0 nM Ca²⁺ - 0 µM Ran	446.63	597.28	463.00	604.67
WT - 0 nM Ca²⁺ - 10 µM Ran	564.39	706.75	580.56	713.78
WT - 2500 nM Ca²⁺ - 0 µM Ran	623.14	754.26	637.95	760.26
WT - 2500 nM Ca²⁺ - 10 µM Ran	521.76	633.36	534.72	638.92
EK - 0 nM Ca²⁺ - 0 µM Ran	270.93	288.18	272.97	288.90
EK - 0 nM Ca²⁺ - 10 µM Ran	339.21	361.89	341.86	362.80
EK - 2500 nM Ca²⁺ - 0 µM Ran	430.22	549.75	443.92	556.03
EK - 2500 nM Ca²⁺ - 10 µM Ran	222.38	215.51	221.51	215.22
Late I _Na Density (pA/pF)
WT - 0 nM Ca²⁺ - 0 µM Ran	6.48	8.89	6.74	9.01
WT - 0 nM Ca²⁺ - 10 µM Ran	11.26	19.76	12.09	20.26
WT - 2500 nM Ca²⁺ - 0 µM Ran	11.08	11.77	11.17	11.80
WT–2500 nM Ca²⁺ - 10 µM Ran	8.17	10.02	8.38	10.11
EK - 0 nM Ca²⁺ - 0 µM Ran	29.25	56.02	31.75	57.68
EK - 0 nM Ca²⁺ - 10 µM Ran	4.15	4.58	4.20	4.60
EK - 2500 nM Ca²⁺ - 0 µM Ran	11.61	12.41	11.71	12.45
EK - 2500 nM Ca²⁺ - 10 µM Ran	13.12	18.37	13.69	18.65
Late Percent (%)
WT - 0 nM Ca²⁺ - 0 µM Ran	1.54	1.50	1.53	1.49
WT - 0 nM Ca²⁺ - 10 µM Ran	2.27	3.71	2.41	3.79
WT - 2500 nM Ca²⁺ - 0 µM Ran	2.80	2.91	2.81	2.92
WT - 2500 nM Ca²⁺ - 10 µM Ran	1.18	1.30	1.19	1.31
EK - 0 nM Ca²⁺ - 0 µM Ran	11.64	16.17	12.13	16.41
EKv0 nM Ca²⁺ - 10 µM Ran	0.92	1.00	0.93	1.00
EK - 2500 nM Ca²⁺ - 0 µM Ran	1.86	1.69	1.84	1.69
EK - 2500 nM Ca²⁺ - 10 µM Ran	3.94	4.96	4.05	5.01
GV-V _1/2 (mV)
WT - 0 nM Ca²⁺ - 0 µM Ran	−44.27	−45.34	−44.40	−45.39
WT - 0 nM Ca²⁺ - 10 µM Ran	−36.12	−33.96	−35.84	−33.87
WT - 2500 nM Ca²⁺ - 0 µM Ran	−40.20	−39.68	−40.13	−39.66
WT - 2500 nM Ca²⁺ - 10 µM Ran	−36.50	−34.66	−36.26	−34.58
EK - 0 nM Ca²⁺ - 0 µM Ran	−29.04	−27.61	−28.86	−27.56
EK - 0 nM Ca²⁺ - 10 µM Ran	−37.06	−37.39	−37.10	−37.40
EK - 2500 nM Ca²⁺ - 0 µM Ran	−33.62	−32.25	−33.44	−32.19
EK - 2500 nM Ca²⁺ - 10 µM Ran	−30.35	−29.25	−30.21	−29.21
GV-z
WT - 0 nM Ca²⁺ - 0 µM Ran	6.79	7.93	6.92	7.99
WT - 0 nM Ca²⁺ - 10 µM Ran	4.84	4.71	4.82	4.71
WT - 2500 nM Ca²⁺ - 0 µM Ran	6.59	7.49	6.70	7.53
WT - 2500 nM Ca²⁺ - 10 µM Ran	5.55	6.11	5.62	6.13
EK - 0 nM Ca²⁺ - 0 µM Ran	3.89	4.17	3.93	4.19
EK - 0 nM Ca²⁺ - 10 µM Ran	4.68	5.21	4.75	5.23
EK - 2500 nM Ca²⁺ - 0 µM Ran	4.36	4.78	4.41	4.80
EK - 2500 nM Ca²⁺ - 10 µM Ran	4.28	4.78	4.34	4.80
SSFI-V _1/2 (mV)
WT - 0 nM Ca²⁺ - 0 µM Ran	−78.24	−75.70	−77.91	−75.59
WT - 0 nM Ca²⁺ - 10 µM Ran	−81.49	−80.21	−81.32	−80.15
WT - 2500 nM Ca²⁺ - 0 µM Ran	−77.46	−74.07	−77.02	−73.92
WT - 2500 nM Ca²⁺ - 10 µM Ran	−81.11	−78.58	−80.79	−78.47
EK - 0 nM Ca²⁺ - 0 µM Ran	−88.67	−85.79	−88.30	−85.67
EK - 0 nM Ca²⁺–10 µM Ran	−92.87	−91.23	−92.66	−91.15
EK - 2500 nM Ca²⁺ - 0 µM Ran	−95.62	−94.16	−95.43	−94.10
EK - 2500 nM Ca²⁺ - 10 µM Ran	−93.54	−91.72	−93.31	−91.64
SSFI-z
WT - 0 nM Ca²⁺ - 0 µM Ran	−4.95	−5.26	−4.99	−5.27
WT - 0 nM Ca²⁺ - 10 µM Ran	−4.02	−4.04	−4.02	−4.04
WT - 2500 nM Ca²⁺ - 0 µM Ran	−4.41	−4.63	−4.44	−4.63
WT - 2500 nM Ca²⁺ - 10 µM Ran	−4.02	−4.05	−4.03	−4.05
EK - 0 nM Ca²⁺ - 0 µM Ran	−3.24	−3.31	−3.25	−3.32
EK - 0 nM Ca²⁺ - 10 µM Ran	−3.21	−3.30	−3.22	−3.31
EK - 2500 nM Ca²⁺ - 0 µM Ran	−3.31	−3.38	−3.32	−3.38
EK - 2500 nM Ca²⁺ - 10 µM Ran	−2.90	−2.85	−2.89	−2.84
−50mV FI τ (ms)
WT - 0 nM Ca²⁺ - 0 µM Ran	2.04	1.77	2.00	1.76
WT - 0 nM Ca²⁺ - 10 µM Ran	2.71	2.58	2.69	2.57
WT - 2500 nM Ca²⁺ - 0 µM Ran	2.19	1.92	2.15	1.91
WT - 2500 nM Ca²⁺ - 10 µM Ran	1.27	1.01	1.24	1.00
EK - 0 nM Ca²⁺ - 0 µM Ran	0.80	0.69	0.78	0.69
EK - 0 nM Ca²⁺ - 10 µM Ran	0.77	0.65	0.75	0.64
EK - 2500 nM Ca²⁺ - - 0 µM Ran	0.60	0.57	0.59	0.57
EK - 2500 nM Ca²⁺ - 10 µM Ran	1.04	0.99	1.03	0.99
−30mV FI τ (ms)
WT–0 nM Ca²⁺ - 0 µM Ran	0.54	0.43	0.53	0.43
WT - 0 nM Ca²⁺–10 µM Ran	0.61	0.52	0.60	0.52
WT - 2500 nM Ca²⁺ - 0 µM Ran	0.36	0.26	0.35	0.25
WT - 2500 nM Ca²⁺ - 10 µM Ran	0.51	0.42	0.50	0.42
EK - 0 nM Ca²⁺ - 0 µM Ran	0.30	0.25	0.29	0.25
EK - 0 nM Ca²⁺ - 10 µM Ran	0.26	0.21	0.25	0.21
EK - 2500 nM Ca²⁺ - 0 µM Ran	0.23	0.20	0.23	0.20
EK - 2500 nM Ca²⁺ - 10 µM Ran	0.31	0.27	0.31	0.27
−10mV FI τ (ms)
WT - 0 nM Ca²⁺ - 0 µM Ran	0.28	0.22	0.27	0.21
WT - 0 nM Ca²⁺ - 10 µM Ran	0.30	0.25	0.29	0.25
WT - 2500 nM Ca²⁺ - 0 µM Ran	0.21	0.16	0.20	0.15
WT–2500 nM Ca²⁺ - 10 µM Ran	0.24	0.19	0.23	0.19
EK - 0 nM Ca²⁺ - 0 µM Ran	0.20	0.16	0.19	0.16
EK - 0 nM Ca²⁺ - 10 µM Ran	0.18	0.15	0.18	0.15
EK - 2500 nM Ca²⁺ - 0 µM Ran	0.15	0.13	0.15	0.13
EK - 2500 nM Ca²⁺ - 10 µM Ran	0.19	0.16	0.18	0.16
+10 mV FI τ (ms)
WT - 0 nM Ca²⁺ - 0 µM Ran	0.19	0.14	0.18	0.14
WT - 0 nM Ca²⁺ - 10 µM Ran	0.20	0.16	0.19	0.16
WT - 2500 nM Ca²⁺ - 0 µM Ran	0.16	0.12	0.16	0.12
WT - 2500 nM Ca²⁺ - 10 µM Ran	0.16	0.13	0.16	0.12
EK - 0 nM Ca²⁺ - 0 µM Ran	0.16	0.13	0.15	0.13
EK - 0 nM Ca²⁺ - 10 µM Ran	0.15	0.12	0.14	0.12
EK - 2500 nM Ca²⁺ - 0 µM Ran	0.12	0.10	0.12	0.10
EK - 2500 nM Ca²⁺ - 10 µM Ran	0.15	0.12	0.14	0.12
1 Hz-y0
WT - 0 nM Ca²⁺ - 0 µM Ran	0.94	0.97	0.94	0.97
WT - 0 nM Ca²⁺ - 10 µM Ran	0.76	0.76	0.76	0.76
WT - 2500 nM Ca²⁺ - 0 µM Ran	0.90	0.93	0.90	0.93
WT - 2500 nM Ca²⁺ - 10 µM Ran	0.83	0.85	0.84	0.85
EK - 0 nM Ca²⁺ - 0 µM Ran	0.86	0.92	0.87	0.92
EK - 0 nM Ca²⁺ - 10 µM Ran	0.83	0.91	0.84	0.92
EK - 2500 nM Ca²⁺ - 0 µM Ran	0.92	0.97	0.92	0.97
EK - 2500 nM Ca²⁺ - 10 µM Ran	0.83	0.90	0.84	0.91
1 Hz-τ1 (s)
WT - 0 nM Ca²⁺ - 0 µM Ran	5.34	6.15	5.43	6.18
WT - 0 nM Ca²⁺ - 10 µM Ran	6.34	7.76	6.51	7.83
WT - 2500 nM Ca²⁺ - 0 µM Ran	42.49	65.65	44.88	66.93
WT - 2500 nM Ca²⁺ - 10 µM Ran	2.23	1.65	2.15	1.63
EK - 0 nM Ca²⁺ - 0 µM Ran	8.14	10.28	8.38	10.38
EK - 0 nM Ca²⁺ - 10 µM Ran	2.22	2.01	2.19	2.00
EK - 2500 nM Ca²⁺ - 0 µM Ran	25.75	50.72	28.04	52.25
EK - 2500 nM Ca²⁺ - 10 µM Ran	1.22	0.77	1.15	0.75
1 Hz-τ2 (s)
WT - 0 nM Ca²⁺ - 0 µM Ran	37.43	35.07	37.13	34.97
WT - 0 nM Ca²⁺ - 10 µM Ran	86.46	129.96	91.00	132.31
WT - 2500 nM Ca²⁺ - 0 µM Ran	50.52	40.70	49.16	40.30
WT - 2500 nM Ca²⁺ - 10 µM Ran	81.65	104.69	84.25	105.85
EK - 0 nM Ca²⁺ - 0 µM Ran	68.52	68.34	68.50	68.33
EK - 0 nM Ca²⁺ - 10 µM Ran	82.26	87.65	82.91	87.89
EK - 2500 nM Ca²⁺ - 0 µM Ran	79.80	102.18	82.29	103.26
EK - 2500 nM Ca²⁺ - 10 µM Ran	43.43	37.52	42.64	37.27
3 Hz-y0
WT - 0 nM Ca²⁺ - 0 µM Ran	0.90	0.99	0.91	1.00
WT - 0 nM Ca²⁺ - 10 µM Ran	0.69	0.75	0.70	0.75
WT - 2500 nM Ca²⁺ - 0 µM Ran	0.83	0.88	0.84	0.88
WT - 2500 nM Ca²⁺ - 10 µM Ran	0.63	0.65	0.63	0.66
EK - 0 nM Ca²⁺ - 0 µM Ran	0.79	0.82	0.79	0.83
EK - 0 nM Ca²⁺ - 10 µM Ran	0.57	0.60	0.57	0.60
EK - 2500 nM Ca²⁺ - 0 µM Ran	0.76	0.78	0.76	0.78
EK - 2500 nM Ca²⁺ - 10 µM Ran	0.68	0.76	0.69	0.76
3 Hz-τ1 (s)
WT - 0 nM Ca²⁺ - 0 µM Ran	2.97	3.29	3.01	3.30
WT - 0 nM Ca²⁺ - 10 µM Ran	0.70	0.46	0.67	0.46
WT - 2500 nM Ca²⁺ - 0 µM Ran	1.38	1.28	1.36	1.27
WT - 2500 nM Ca²⁺ - 10 µM Ran	0.98	0.93	0.97	0.92
EK - 0 nM Ca²⁺ - 0 µM Ran	3.07	3.69	3.14	3.72
EK - 0 nM Ca²⁺ - 10 µM Ran	1.47	1.29	1.45	1.28
EK - 2500 nM Ca²⁺ - 0 µM Ran	2.27	2.01	2.24	2.00
EK - 2500 nM Ca²⁺ - 10 µM Ran	0.84	0.58	0.81	0.57
3 Hz-τ2 (s)
WT - 0 nM Ca²⁺ - 0 µM Ran	14.24	10.80	13.75	10.66
WT - 0 nM Ca²⁺ - 10 µM Ran	15.28	13.72	15.08	13.65
WT - 2500 nM Ca²⁺ - 0 µM Ran	39.52	40.39	39.63	40.43
WT - 2500 nM Ca²⁺ - 10 µM Ran	20.81	26.32	21.43	26.60
EK - 0 nM Ca²⁺ - 0 µM Ran	54.26	61.55	55.14	61.90
EK - 0 nM Ca²⁺ - 10 µM Ran	31.12	36.95	31.81	37.24
EK - 2500 nM Ca²⁺ - 0 µM Ran	43.81	68.26	46.41	69.75
EK - 2500 nM Ca²⁺ - 10 µM Ran	5.29	4.15	5.13	4.11

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Table 6 Values at 37 °C and 41 °C based on Q₁₀ and Arrhenius Calculations.

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