Figure 4 | Scientific Reports

Figure 4

From: A Functional Signature Ontology (FUSION) screen detects an AMPK inhibitor with selective toxicity toward human colon tumor cells

Figure 4

5-OH-S treatment preferentially inhibits colon cancer cell survival. (A) Colony formation following treatment with 7.5 μM 5-OH-S. ****p < 0.0001. (B) Dose-dependent apoptosis in HCT116 and SW480 colon cancer cells and HCECs following treatment with 5-OH-S. (C)Immunoblot of PARP cleavage in HCT116 and SW480 cells following treatment with 7.5 μM 5-OH-S for 48 hours.

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