Figure 7
Comparison with UNC, MDA, and TCGA classification systems. (A) Comparison of the LundTax and UNC classification calls in the TCGA bladder cancer cohort. Top bar shows the LundTax classification of the TCGA samples. Stromal and immune score bars show the estimated scores for tumor purity based on the ESTIMATE tool12. Color codes; high score (red) indicates high-level infiltration; low score (blue) indicates low-level infiltration. Ba/Sq ratios were calculated for each sample as KRT5 + KRT14 − FOXA1 − GATA3 using log2 mRNA expression values. High ratio (red) indicate a Ba/Sq subtype, low ratio (blue) indicate non-Ba/Sq subtype. Bar indicated by “BASE47” shows classification using the BASE47 classifier3. Color codes, blue, Luminal; red, Basal. Bar indicated by “UNC” shows BASE47 classification with the Claudin-low 40 (BCL40)4 classification added. Color codes; blue, Luminal; red, Basal; green, Claudin-low. In the lower panels, heat maps of BASE47 and BCL40 signature genes are shown. (B) Comparison of the LundTax and MDA subtypes5. Color codes for the MDA classification; blue, Luminal; light blue, Luminal-TP53, red, Basal; orange, Basal-TP53; green, Double negative. (C) Comparison of the LundTax and TCGA I-IV subtypes7. Color codes for the TCGA classification; green, Cluster I; blue, Cluster II; red Cluster III; pink, Cluster IV. Vertical white lines separate major LundTax molecular subtypes; dotted lines, separate subgroups of subtypes.
