Figure 1 | Scientific Reports

Figure 1

From: Neutrophil extracellular trap-microparticle complexes enhance thrombin generation via the intrinsic pathway of coagulation in mice

Figure 1

NET formation in abdominal sepsis. (A) Representative western blot and aggregate data on citrullinated histone 3 in neutrophils isolated from the blood from sham and CLP animals. Plasma levels of (B) cf-DNA and (C) DNA-histone complexes were determined 24 h after CLP. (D) TG over time, (E) peak and (F) total levels of TG were determined as described in Material and Methods. Mice underwent CLP or the identical laparotomy and resuscitation procedures, but the cecum was neither ligated nor punctured (Sham). Animals received intraperitoneal injections of DNAse (5 mg/kg), an anti-Ly-6G antibody (Anti-Ly-6G ab, 20 mg/kg) or vehicle. Data are presented as mean ± SEM and n = 5. *P < 0.05 vs. Sham and #P < 0.05 vs. Vehicle + CLP.

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