Table 2 Association of TERT promoter mutation with clinico-pathological features and TERT expression.

From: Association of clinicopathological features and prognosis of TERT alterations in phyllodes tumor of breast

Features N(%)

 

WT

Mutant

Total

P-value

Age

Mean

40.7

46.3

42.2

0.053

SD

14.3

9.6

13.3

 

Median

41.0

45.5

43.0

 

Range

16–86

33–69

  

Tumor size

Mean

53.1

71.6

58.3

0.134

SD

36.3

59.8

44.6

 

Median

45.0

52.5

45.0

 

Range

12–220

17–280

  

Diagnosis

Benign

45 (78.9)

12 (21.1)

57

0.204

Borderline

15 (60.0)

10 (40.0)

25

 

Malignant

10 (71.4)

4 (28.6)

14

 

(Borderline/malignant)

25

14

39

(0.108)

Total

70

26

96

 

Border

Pushing

38 (80.9)

9 (19.1)

47

0.161

Focal infiltrative

15 (60.0)

10 (40.0)

25

 

Infiltrative

15 (71.4)

6 (28.6)

21

 

Total

68

25

93

 

Mitotic count

<5

46 (76.7)

14 (23.3)

60

0.547

5–9

15 (65.2)

8 (34.8)

23

 

>9

9 (69.2)

4 (30.8)

13

 

Total

70

26

96

 

Pleomorphism

Mild

43 (72.9)

16 (27.1)

59

0.887

Moderate

21 (75.0)

7 (25.0)

28

 

Severe

6 (66.7)

3 (33.3)

9

 

Total

70

26

96

 

Cellularity

Mild

40 (75.5)

13 (24.5)

53

0.597

Moderate

17 (65.4)

9 (34.6)

26

 

Severe

13 (76.5)

4 (23.5)

17

 

Total

70

26

96

 

Stromal overgrowth

No

51 (81.0)

12 (19.0)

63

0.032

Focal

8 (50.0)

8 (50.0)

16

 

Present

11 (64.7)

6 (35.3)

17

 

Total

70

25

96

 

All

Stromal IHC

Low

30 (76.9)

9 (23.1)

39

0.122

Intermediate

24 (80.0)

6 (20.0)

30

 

(Low/Intermediate)

54

15

69

(0.042)

High

13 (56.5)

10 (43.5)

23

 

Total

67

25

92

 

Epithelial IHC

Low

32 (72.7)

12 (27.3)

44

0.989

Intermediate

18 (72.0)

7 (28.0)

25

 

(Low/ Intermediate)

50

19

69

(0.892)

High

17 (73.9)

6 (26.1)

23

 

Total

67

25

92

 

Benign

Stromal IHC

Low

21 (84.0)

4 (16.0)

25

0.636

Intermediate

13 (76.5)

4 (23.5)

17

 

(Low/Intermediate)

33

8

42

(0.452)

High

10 (71.4)

4 (28.6)

14

 

Total

44

12

56

 

Epithelial IHC

Low

15 (75.0)

5 (25.0)

20

0.862

Intermediate

15 (78.9)

4 (21.1)

19

 

(Low/Intermediate)

30

9

39

(0.738)

High

14 (82.4)

3 (17.6)

17

 

Total

44

12

56

 

Borderline

Stromal IHC

Low

5 (55.6)

4 (44.4)

9

0.024

Intermediate

8 (80.0)

2 (20.0)

10

 

(Low/Intermediate)

13

6

19

(0.012)

High

0 (0)

4 (100)

4

 

Total

23

13

36

 

Epithelial IHC

Low

10 (71.4)

4 (28.6)

14

0.179

Intermediate

1 (25.0)

3 (75.0)

4

 

(Low/Intermediate)

11

7

18

(0.618)

High

2 (40.0)

3 (60.0)

5

 

Total

23

10

23

 

Malignant

Stromal IHC

Low

4 (80.0)

1 (20.0)

5

0.420

Intermediate

3 (100)

0 (0)

3

 

(Low/Intermediate)

7

1

8

0.510

High

3 (60.0)

2 (40.0)

5

 

Total

10

3

13

 

Epithelial IHC

Low

7 (70.0)

3 (30.0)

10

0.557

Intermediate

2 (100)

0 (0)

2

 

(Low/Intermediate)

9

3

12

(1.000)

High

1 (100)

0 (0)

1

 

Total

10

3

13

 
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