Table 3 Effects of (CAG)n size in polyQ-related genes on age at onset for patients with MSA.

From: Analysis of (CAG)n expansion in ATXN1, ATXN2 and ATXN3 in Chinese patients with multiple system atrophy

Locus

Group (CAGs)

n

Age at onset

P-value

ATXN1

short

104

52.5 ± 7.2

0.072

long

96

54.3 ± 7.5

ATXN2

short-medium

181

53.4 ± 7.2

0.842

medium

11

54.1 ± 8.5

long

8

51.6 ± 10.4

ATXN3

short-medium

85

53.3 ± 7.2

0.898

long

115

53.4 ± 7.5

  1. *Group: Long alleles of ATXN1, ATXN2, and ATXN3 were divided into several groups as follows:
  2. ATXN1: short: ≤29 CAGs; long: >29 CAGs.
  3. ATXN2: short: <22 CAGs; short-medium: 22 CAGs; medium: 23–26 CAGs; long: 27–32 CAGs.
  4. ATXN3: short: <19 CAGs; short-medium: 19–25 CAGs; long: 26–40 CAGs.
  5. P-value estimated by one-way ANOVA or Kruskal-Wallis test.
Back to article page