Figure 15 | Scientific Reports

Figure 15

From: In silico screening for human norovirus antivirals reveals a novel non-nucleoside inhibitor of the viral polymerase

Figure 15

Overlap of site-A (suramin) and site-B (PPNDS) on the norovirus RdRp. Superposition of the MNV RdRp structure (dark green ribbon) in complex with suramin (carbon atoms in dark purple) and the human norovirus RdRp structure (salmon ribbon) in complex with PPNDS (carbon atoms in pink). 54 (carbon atoms in lilac) occupies the central core of site-B and extends up to the initial part of site-A (Arg392 area), where suramin places its sulphate head.

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