Figure 7

Alternative method for the preparation of the free acid derivatives (i) β-alanine, AcOH, 100 °C 1 h; (ii) K2CO3, DMF, r.t. o.n., 60 °C 72 h; (iii) Na2CO3, Pd(PPh3)2, THF/H2O, r.t. 8 h, 60 °C 12 h.
Alternative method for the preparation of the free acid derivatives (i) β-alanine, AcOH, 100 °C 1 h; (ii) K2CO3, DMF, r.t. o.n., 60 °C 72 h; (iii) Na2CO3, Pd(PPh3)2, THF/H2O, r.t. 8 h, 60 °C 12 h.