Figure 5
Canonical pathway and network analysis by IPA. The 13 enriched proteins in MSC-PLT were analysed through the use of Ingenuity Pathway Analysis (IPA, QIAGEN INC., https://www.qiagenbioinformatics.com/products/ingenuity-pathway-analysis). (a) Significantly altered canonical pathways associated with the enriched surface proteins in MSC-PLT. The canonical pathways included in this analysis are shown in the x-axis of the bar chart. The y-axis indicates the statistical significance calculated using the right-tailed Fisher exact test. (b) Graphical representation of the top ranked network, related to inflammatory responses, with a score of 28, as nodes (molecules) and edges (biological relationship between the different molecules). Red nodes represent the investigated enriched proteins involved in this network. Meanings of node shapes and edges are indicated in the legend within the figure.
