Table 6 ADME parameters of zerumbone and α-humulene computed using ACD iLab.
From: Zerumbone reduces proliferation of HCT116 colon cancer cells by inhibition of TNF-alpha
ADME parameters | Zerumbone | α-humulene |
|---|---|---|
Absorption | 8.43 × 10−4 cm/s | 8.46 × 10−4 cm/s |
Absorption rate Ka | 0.058 min−1 | 0.058 min−1 |
Blood-Brain Barrier (BBB) | ||
LogPS | −1 | −1 |
LogPB | 0.37 | 0.35 |
Log(PS*fu, brain) | −2.9 | −3.2 |
LogBB | 0.37 | 0.35 |
LogPS | −1 | −1 |
DBP | 96.92% | 98.59% |
Vd | 2.23 L/kg | 3.71 L/kg |
Pgp Substrate | Non-substrate | Non-substrate |
Pgp Inhibitor | Non-inhibitor | Non-inhibitor |
