Table 7 LD50 analysis of Zerumbone and α-humulene.
From: Zerumbone reduces proliferation of HCT116 colon cancer cells by inhibition of TNF-alpha
LD50 Species /Administration route | LD50 of Zerumbone (mg/kg) | Reliability | LD50 of α-humulene (mg/kg) | Reliability |
|---|---|---|---|---|
Mouse/Intraperitoneal | 480 | Moderate(0.66) | 150 | Borderline(0.37) |
Mouse/Oral | 2700 | Moderate(0.51) | 960 | Borderline(0.38) |
Mouse/Intravenous | 100 | Moderate(0.51) | 34 | Not Reliable(0.27) |
Mouse/Subcutaneous | 1400 | Borderline(0.44) | 560 | Moderate(0.55) |
Rat/Intraperitoneal | 210 | Borderline(0.38) | 110 | Borderline(0.44) |
Rat/Oral | 3400 | High(0.8) | 1400 | Borderline(0.44) |
