Figure 2
From: Cedratvirus getuliensis replication cycle: an in-depth morphological analysis
Electron-lucent viral factory and cytoplasmic modifications induced by Cedratvirus getuliensis modification. (A) C. getuliensis presents an electron-lucent viral factory (contoured in red and in detail) not easily distinguished from the rest of the cytoplasm and observed at the perinuclear region. Different stages of viral particle morphogenesis could also be observed within the viral factory. (B) Abundant presence of mitochondria inside (contoured in red) the viral factory (contoured in blue). (C) Lysosomal accumulation and polarization in the host cytoplasm (contoured in yellow). (D) Intensified membrane traffic in the host cytoplasm (yellow arrow). (E) Treatment with BFA reduces the viral titer after 24 hours of infection. (F) Infected cells treated with BFA presented membrane degradation after 8 hours of infection. VF: Viral factory. Nu: Nucleus. Mi: Mitochondria. Image A-right was obtained by TEM and graphically highlighted by using IOS image visualization software.
