Figure 2 | Scientific Reports

Figure 2

From: Using massively parallel shotgun sequencing of maternal plasmatic cell-free DNA for cytomegalovirus DNA detection during pregnancy: a proof of concept study

Figure 2

Analysis of the presence of HCMV DNA in calibration samples. (A) Representation of the number of reads mapped to the masked HCMV reference for positive calibration samples (with viral load between 10 copies/mL and 2500 copies/mL) and negative controls. The mean number of reads ± standard error of the mean (SEM) is represented for both groups. The range values of read numbers [min-max] and sample number in each group are also reported. ***Represents a p-value < 0.001 (Mann–Whitney test). (B) Representation of the mean depth of positive calibration samples (with a viral load between 10 copies/mL and 2500 copies/mL) and negative controls to the masked HCMV reference. The mean depth ± standard error of the mean (SEM) is represented for both groups. The range values of read numbers [min-max] and sample numbers in each group are also reported. ***Represents a p-value < 0.001 (Mann–Whitney test).

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