Figure 6
From: Statistically derived asymmetric membrane potentials from α-helical and β-barrel membrane proteins
(A) Correlation between predicted and experimental ∆∆Gs for CLS (the C-terminal portion of L-Selectin, values were taken from Fig. 2 in Fleishman’s paper12) depending on the depth in the membrane with red being the external side and blue being the cytoplasmic/periplasmic side of the membrane. The Pearson correlation coefficient is 0.455 for this α-helical membrane protein, which is at the upper limit of what other methods predict on a membrane protein database43. (B) Correlation between predicted and experimentally determined folding free energies for five β-barrels and two α-helical proteins. Values were taken from Fleming’s review44 and only the middle value for OmpA was taken (see Table 1 in reference44). The Pearson correlation coefficient is 0.197.
