Table 2 Forty top-ranking putative virulence proteins of Pythium insidiosum, based on sequence similarity and probability (E-value), obtained by a BLAST search against the MvirDB database (see the Methods). The proteins that can be mapped with at least two LC-MS/MS-generated peptides are indicated in the last column.
Protein ID | VFID | Virulence factor type | Description | Organism | Identities (%) | E-value | Number of mapped peptides |
|---|---|---|---|---|---|---|---|
PINS01090021A | 26447 | Virulence protein | Heat shock protein 70 | Toxoplasma gondii | 76.4 | 0.0E + 00 | 12 |
PINS03900001A | 26447 | Virulence protein | Heat shock protein 70 | Toxoplasma gondii | 76.2 | 0.0E + 00 | — |
PINS00530003B | 26381 | Virulence protein | Heat shock protein 70 | Cryptosporidium parvum | 71.2 | 0.0E + 00 | 82 |
PINS01800019A | 26447 | Virulence protein | Heat shock protein 70 | Toxoplasma gondii | 66.2 | 0.0E + 00 | 6 |
PINS01150027A | 26468 | Virulence protein | Heat shock protein 70 | Eimeria tenella | 65.0 | 0.0E + 00 | 37 |
PINS00920015C | 12025 | Virulence protein | Urease | Oryza sativa | 64.5 | 0.0E + 00 | 40 |
PINS01090006A | 26447 | Virulence protein | Heat shock protein 70 | Toxoplasma gondii | 61.2 | 0.0E + 00 | — |
PINS00020096A | 26447 | Virulence protein | Heat shock protein 70 | Toxoplasma gondii | 57.6 | 0.0E + 00 | 20 |
PINS02610001A | 26447 | Virulence protein | Heat shock protein 70 | Toxoplasma gondii | 57.6 | 0.0E + 00 | — |
PINS01620006A | 15128 | Virulence protein | Chaperone protein ClpB | Francisella tularensis | 55.1 | 0.0E + 00 | 32 |
PINS04750002A | 26434 | Virulence protein | Carbamoyl phosphate synthetase II | Toxoplasma gondii | 53.3 | 0.0E + 00 | 30 |
PINS02520008A | 26434 | Virulence protein | Carbamoyl phosphate synthetase II | Toxoplasma gondii | 51.5 | 0.0E + 00 | 24 |
PINS00060002C | 26434 | Virulence protein | Carbamoyl phosphate synthetase II | Toxoplasma gondii | 48.0 | 0.0E + 00 | 102 |
PINS00250041A | 27174 | Virulence protein | Oligopeptidase B | Trypanosoma brucei brucei | 47.4 | 0.0E + 00 | 4 |
PINS00320055A | 15128 | Virulence protein | Chaperone protein ClpB | Francisella tularensis | 47.1 | 0.0E + 00 | 16 |
PINS01420022C | 11169 | Protein toxin | Tripeptidyl peptidase 2 | Mus musculus | 34.8 | 0.0E + 00 | 24 |
PINS05940001B | 26381 | Virulence protein | Heat shock protein 70 | Cryptosporidium parvum | 73.5 | 1.0E-177 | 17 |
PINS00130063A | 26455 | Virulence protein | Eukaryotic translation initiation factor 4 A | Toxoplasma gondii | 72.9 | 1.0E-173 | 31 |
PINS00020065A | 8350 | Virulence protein | Chaperonin GroEL | Legionella pneumophila | 57.0 | 3.0E-159 | 61 |
PINS00550026A | 8728 | Virulence protein | Phosphoglucomutase | Brucella melitensis | 50.6 | 2.0E-158 | 50 |
PINS00550030A | 8728 | Virulence protein | Phosphoglucomutase | Brucella melitensis | 50.4 | 7.0E-158 | 80 |
PINS01120025A | 26459 | Virulence protein | Peroxisomal catalase | Toxoplasma gondii | 59.6 | 9.0E-157 | 8 |
PINS01120010A | 26459 | Virulence protein | Peroxisomal catalase | Toxoplasma gondii | 59.5 | 3.0E-156 | — |
PINS01900015C | 12413 | Protein toxin | Transcription factor site-1 protease | Homo sapiens | 41.6 | 2.0E-155 | — |
PINS00150050B | 20164 | Pathogenicity island | Asparaginyl-tRNA synthetase | Salmonella enterica | 58.0 | 1.0E-153 | 25 |
PINS04900006A | 26455 | Virulence protein | Eukaryotic translation initiation factor 4 A | Toxoplasma gondii | 64.3 | 7.0E-152 | — |
PINS00400067B | 26455 | Virulence protein | Eukaryotic translation initiation factor 4 A | Toxoplasma gondii | 64.6 | 8.0E-151 | — |
PINS01020032C | 27223 | Virulence protein | 80 kDa prolyl oligopeptidase | Trypanosoma cruzi | 41.3 | 1.0E-147 | 29 |
PINS00400051A | 26455 | Virulence protein | Eukaryotic translation initiation factor 4 A | Toxoplasma gondii | 63.0 | 7.0E-146 | — |
PINS00050027A | 19089 | Pathogenicity island | Methylmalonyll-CoA mutase | Streptomyces coelicolor | 50.3 | 4.0E-145 | — |
PINS02120014C | 12413 | Protein toxin | Transcription factor site-1 protease | Homo sapiens | 40.2 | 5.0E-142 | 30 |
PINS00780045C | 15600 | Pathogenicity island | GDP-mannose 4,6-dehydratase | Bradyrhizobium japonicum | 66.2 | 4.0E-139 | 17 |
PINS07960001C | 15600 | Pathogenicity island | GDP-mannose 4,6-dehydratase | Bradyrhizobium japonicum | 63.8 | 8.0E-137 | 9 |
PINS01820002A | 18499 | Pathogenicity island | CTP synthetase | Streptococcus agalactiae | 44.7 | 3.0E-125 | 36 |
PINS00650054A | 26447 | Virulence protein | Heat shock protein 70 | Toxoplasma gondii | 42.8 | 2.0E-121 | — |
PINS01020025B | 7573 | Virulence protein | Nonribosomal peptide synthetase DhbF | Bacillus anthracis | 29.0 | 1.0E-113 | 54 |
PINS01050006C | 18594 | Pathogenicity island | Polynucleotide phosphorylase/polyadenylase | Streptococcus agalactiae | 37.7 | 2.0E-113 | — |
PINS01020014C | 7573 | Virulence protein | Nonribosomal peptide synthetase DhbF | Bacillus anthracis | 28.9 | 3.0E-113 | 28 |
PINS00170005A | 20164 | Pathogenicity island | Asparaginyl-tRNA synthetase | Salmonella enterica | 46.7 | 6.0E-113 | 27 |
PINS00080003C | 28065 | Virulence protein | Dynamin-like protein | Giardia intestinalis | 43.7 | 1.0E-110 | 11 |
