Table 4 Risk factors for the intolerable side effects derived from univariate analysis.

From: Intolerable side effects during propranolol therapy for infantile hemangioma: frequency, risk factors and management

Variable

With intolerable side effects (n = 26)

Without intolerable side effects (n = 1234)

P-values†

95% Confidence Interval

Age (d)*

  

0.001

1.838–20.637

 <90

23 (88.5)

595 (48.2)

  

 90–180

3 (11.5)

478 (38.7)

  

å 180

0 (0)

161 (13.0)

  

Gender

  

0.843

0.455–2.626

 Male

7 (26.9)

311 (25.2)

  

 Female

19 (73.1)

923 (74.8)

  

Gestational age

  

0.035

1.092–5.640

 Born prematurely

9 (34.6)

217 (17.6)

  

 Term born

17 (65.4)

1017 (82.4)

  

Body weight (kg)*

  

0.024

1.103–9.889

 <5

4 (15.4)

60 (4.8)

  

 5–10

22 (84.6)

1090 (88.5)

  

 å 10

0 (0)

82 (6.6)

  
  1. *Age when starting propranolol treatment; body weight when starting propranolol treatment.
  2. †The differences are statistically significant if P < 0.05.
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