Figure 1
From: Rare variants in drug target genes contributing to complex diseases, phenome-wide
Phewas-view plot of clinical laboratory measures. (A) Represents clinical laboratory measurement gene based associations for results with P-value < 0.001. The Y-axis lists all phenotypes. Triangles represent the –log10 P-value of associations on the left, with normalized beta in on the right with standard error bars. Points are colored based on the filter category. The direction of the triangle corresponds to the direction of effect: up is positive, down is negative. The results for alanine aminotransferase (ALT) are plotted separately in (B) due to the significance of tshe results on a different scale from the rest of the results. (C) Is a Manhattan plot of associations with P-value < 0.001 for ICD-9 code based case/control diagnoses. The x-axis corresponds to ICD-9 category and y-axis corresponds to the −log10(P-value) of the association and the points are colored based on the ICD-9 category. Within each diagnosis category the plotted points are ordered from most significant associations to the least significant associations.
