Figure 3
From: Rare variants in drug target genes contributing to complex diseases, phenome-wide
(A) Shows the top 5 results from each rare variant filtering strategy and corresponding –log10(P-value) and magnitude and direction of effect (boxes linked to the data points) from other filtering strategies for the same gene-phenotype associations for clinical lab measures. The x axis shows the clinical lab name and y-axis shows the –log10(p-value). Beta coefficient are represented by numbers next to points which are color coded by filter category and shape corresponds to gene name. (B) Shows the top 5 results from each rare variant filtering strategy and corresponding –log10(P-value) and magnitude and direction of effect (boxes linked to the data points) from other filtering strategies for the same gene-phenotype associations for ICD-9 based diagnoses. The x axis shows the general ICD-9 category the diagnosis was grouped into and y-axis shows the –log10(p-value). Beta coefficients are represented by numbers next to points, are color coded by filter category, and the shape corresponds to the specific gene listed in the legend.
