Figure 5
From: Stimulation of alpha2-adrenergic receptors impairs influenza virus infection
Efficacy of clonidine against H1N1 influenza viruses in mice. Five mice (A and B) and three mice (C) per group were intranasally infected with 370,000 pfu of mouse-adapted pandemic A/California/04/2009. The infected mice were given clonidine orally at the indicated doses once daily for 5 days beginning 2 h pi. Survival (A) and body weight (B) were monitored daily for 16 days. The survival rate was determined by death or a cut-off of 35% lost body weight. *P < 0.05. (B) Data are shown as means of surviving mice. (C) Lung virus titers on days 3 and 6 pi were determined by using plaque assays. Data are shown as means ± SD of three mice.
