Figure 2 | Scientific Reports

Figure 2

From: Structural modelling of the DNAJB6 oligomeric chaperone shows a peptide-binding cleft lined with conserved S/T-residues at the dimer interface

Figure 2

The conformational flexibility of DNAJB6 probed using normal mode analysis. The structural model of DNAJB6 monomer (selected as best fit, Fig. 1) was used for analysis. (A) The fluctuations of mode 9 reveal that the region 195–205 (within blue box) undergoes maximum conformational changes. (B) The regions with maximum (red) and minimum (blue) deviation represented using the contact map also reflect the previous observation. (C) The vector representation of the Cα displacements, with each vector represented as arrows along with their relative direction of motion and magnitude, also reveals the region with maximum displacement (within ellipse). The Cα trace is shown for reference colored from red (N-terminal) to blue (C-terminal). (D) A cartoon representation, indicating the loop region with the maximum fluctuation colored in blue, while the other two loops are colored red and pink.

Back to article page