Figure 1 | Scientific Reports

Figure 1

From: Dynamic metabolic patterns tracking neurodegeneration and gliosis following 26S proteasome dysfunction in mouse forebrain neurons

Figure 1

Cortex and hippocampus of Psmc1fl/fl;CaMKIIα-Cre mice display metabolic patterns distinct from controls. (A) PCA scores plots illustrating the difference between metabolic profiles of control and Psmc1fl/fl;CaMKIIα-Cre mouse hippocampi and cortices at 4 and 6 weeks-old. (B) PCA loadings from 4.14 to 0.7 ppm demonstrating the contribution of individual metabolites to the metabolic profiles of control and Psmc1fl/fl;CaMKIIα-Cre mouse hippocampi and cortices at 4 and 6 weeks-old. Positive and negative loadings indicate a decrease and increase in Psmc1fl/fl;CaMKIIα-Cre mice respectively. A: choline-containing compounds; B: taurine; C: glutamine; D: N-acetyl aspartate; E: branch-chained amino acids; F: glycine; G: creatine; H: lactate; I: serine; X: unknown AB system (possibly due to contamination). PCA model figures: R2X(1PC) = 0.333 (4 week-old) and 0.581 (6 week-old) hippocampus; R2X(1PC) = 0.660 (4 week-old) and 0.740 (6 week-old) cortex.

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