Table 1 ORs and 95% CIs for NSCLC in relation to genotypes of studied NF-kB2 SNPs.

From: NF-kB2 Genetic Variations are Significantly Associated with Non-Small Cell Lung Cancer Risk and Overall Survival

SNP

Counts

χ2

Univariate analysisb

Genotype

Cases

n (%)

Controls

n (%)

P a

P

OR (95% CI)

Total

268

279

—

—

—

rs7897947

264

279

—

—

—

ΤΤ

145 (54,9)

125 (44,8)

0.052

—

1.000

GT

89 (33,7)

120 (43,0)

0.016

0.639 (0.444–0.920)

GG

30 (11,4)

34 (12,2)

0.326

0.761 (0.441–1.313)

ΤΤ + GΤ vs

GG

234 (88,6)

30 (11,4)

245 (87,8)

34 (12,2)

 

0.766

1.082 (0.642–1.825)

ΤΤ vs

GT + GG

145 (54,9)

119 (45,1)

125 (44,8)

154 (55,2)

 

0.019

1.501 (1.070–2.106)

T allele

379 (71.8)

370 (66.3)

0.051

0.052

1.292 (0.998–1.673)

G allele

149 (28.2)

188 (33.7)

0.774 (0.598–1.002)

rs12769316

242

278

—

—

—

AA

20 (8.3)

7 (2.5)

0.012

 

1.000

AG

62 (25.6)

71 (25.5)

0.005

0.280 (0.116–0.679)

GG

160 (66.1)

200 (71.9)

0.012

0.306 (0.121–0.771)

AA + AG vs

GG

82 (33.9)

160 (66.1)

78 (28.1)

200 (71.9)

 

0.151

1.314 (0.905–1.909)

AA vs

AG + GG

20 (8.3)

222 (91.7)

7 (2.5)

271 (97.5)

 

0.005

3.488 (1.448–8.399)

A allele

102 (21.1)

85 (15.3)

0.015

0.016

1.480 (1.077–2.033)

G allele

382 (78.9)

471 (84.7)

 

0.676 (0.492–0.929)

rs11574852

261

278

—

—

—

AA

239 (91.6%)

254 (91.4%)

0.624

—

1.000

AC

22 (8.4%)

23 (8.3%)

0.999

0.984 (0.534–1.812)

CC

0 (0.0%)

1 (0.4%)

—

—

A allele

0,9579

0,9585

0.821

0.821

1.070 (0.596–1.922)

C allele

0,0421

0,0415

0.935 (0.520–1.679)

  1. aP derives from the χ2 test and refers to overall association of genotypes with NSCLC risk. bP, OR and 95% CI derived from logistic regression analysis. Abbreviations: CI, confidence interval; OR, odds ratios.
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