Table 3 Multivariate analysis of OS of NSCLC patients according to genotypes of polymorphisms rs7897947, rs12769316 and rs11574852.
Polymorhism | Base change | Multivariate analysis 2-year OS | Multivariate analysis 3-year OS | Multivariate analysis 5-year OS | |||
|---|---|---|---|---|---|---|---|
HR (95% CI) | Cox proportional Hazard models P | HR (95% CI) | Cox proportional Hazard models P | HR (95% CI) | Cox proportional Hazard models P | ||
rs7897947 dominant (TTvsGT + GG) recessive (TT + GTvsGG) | T > G | 1.591 (1.045–2.423) 0.826 (0.419–1.630) | 0.030 0.582 | 1.503 (1.044–2.165) 1.147 (0.590–2.231) | 0.028 0.685 | 1.360 (0.977–1.893) 1.202 (0.669–2.161) | 0.069 0.538 |
rs12769316 dominant (AA + GAvsGG) recessive (AAvsGA + GG) | G > A | 1.195 (0.773–1.849) 1.391 (0.689–2.808) | 0.423 0.358 | 1.103 (0.750–1.622) 1.324 (0.702–2.495) | 0.618 0.386 | 0.974 (0.678–1.400) 1.025 (0.548–1.919) | 0.887 0.937 |
rs11574852 (AAvsAC) | A > C | 1.484 (0.645–3.411) | 0.353 | 0.849 (0.604–2.126) | 0.609 | 1.041 (0.558–1.942) | 0.899 |
