Table 5 Distribution of the inferred metabolic phenotype and scores by district, and Kolmogorv-Smirnov (K-S) D statistics with associated P values to test the normal distribution of data.

From: Human cytochrome P450 2B6 genetic variability in Botswana: a case of haplotype diversity and convergent phenotypes

District

PM (−3)

Expected metabolic phenotypes (with scores)

PM (−2)

I (−1)

EM (0)

I (+1)

UR (+2)

Total

K-S D statistic (P)

Serowe/Palapye

0

4

86

150

14

2

256

0.34 (n.s.)

Chobe

1*

4*

56

90

5

0

156

0.38 (n.s.)

Ghanzi

0

3

55

97

3

0

158

0.38 (n.s.)

Total

1

11

197

337

22

2

570

0.36 (n.s.)

  1. Score attribution was made according to: 516 TT = −2; 516 GT = −1; 516 GG = 0; 785 GG = +2; 785 AG = +1; 785 AA = 0; 983 CC = −2; 983 TC = −1; 983 TT = 0. We performed a summation for each genotype (516, 983 and 785) per sample to obtain the “metabolic score”. PM: poor metabolisers; I: intermediate metabolisers; EM: extensive metabolisers; UR: ultra-rapid metabolisers. (*two 983CC genotypes were found in Chobe).
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